Expressions of p57^kip2 and cyclin D1 Proteins in Epithelial Ovarian Carcinoma and Their Clinical Significance

Objective To investigate the relationship of p57^kip2 and cyclin D1 expressions with clinicopathological features of epithelial ovarian tumor. Methods SP immunohistochemical technique was applied to detect the expressions of p57^kip2 and cyclin D1 proteins in tissues of 41 patients with malignant epithelial ovarian cancer, 12 with borderline tumor, 24 with benign tumor and 12 normal ovaries. Results The positive-expression of p57^kip2 and cyclin D1 was91.7%(11/12), 79.2%(19/24), 58.3%(7/12), 46.3%(19/41) and 8.3% (1/12), 29.2%(7/24), 50%(6/12), 75.6%(31/41)，respectively in normal, benign, borderline, and malignant tissues. There were significant differences betweenp57^kip2 and cyclin D1 proteins in normal group compared with the malignant,andthe benign compared with the malignant. In malignant ovarian tumors,overexpression of cyclin D1 and low-expression of p57^kip2 are significantly associated with high tumor grade, advanced clinical stage, and lymph nodemetastasis. Expression of cyclin D1 was negatively correlated with expression of p57^kip2. Conclusion p57^kip2 and cyclin D1 playedimportant roles in occurrence and development of epithelial ovarian cancer. Overexpression of cyclin D1 and low-expressionof p57^kip2 provide important implications of malignancy and prognosis for epithelial ovarian carcinoma.