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HAN Xiang-chun, KANG Jin-wang, ZHENG Li-qiang, ZUO Lian-fu. Expression of Wnt1，β-catenin，PC and cyclinD1 Proteins in Gastric Carcinoma[J]. Cancer Research on Prevention and Treatment, 2011, 38(02): 163-166. DOI: 10.3971/j.issn.1000-8578.2011.02.012
Citation: HAN Xiang-chun, KANG Jin-wang, ZHENG Li-qiang, ZUO Lian-fu. Expression of Wnt1，β-catenin，PC and cyclinD1 Proteins in Gastric Carcinoma[J]. Cancer Research on Prevention and Treatment, 2011, 38(02): 163-166. DOI: 10.3971/j.issn.1000-8578.2011.02.012
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Expression of Wnt1，β-catenin，PC and cyclinD1 Proteins in Gastric Carcinoma

  • 1.Department of Pathology，The Second Affiliated Hospital，Hebei North University，Zhangjiakou 075100，China；2.Department of Dermatology，The 251st Hospital of Chinese PLA;3.Institute of Oncology of The Fourth Affiliated Hospital，Hebei Medical University

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  • Received Date: February 08, 2010
  • Revised Date: May 26, 2010
    Abstract
  • ObjectiveTo detect the expression of Wnt1，β-catenin，APC and cyclin D1 proteins in human gastric carcinoma. Methods The immunohistochemical staining(LASB) was performed in 45 specimens and normal tissue adjacent to tumor border (>5cm). Results In 45 cases gastric carcinoma，the positive rates of Wnt1，β-catenin and cyclin D1 were 57.78％,73.33％ and 51.11％ respectively. In comparison，statistic difference is apparent because of their absence (excluding membrane expression of β-catenin) in normal tissue (P<0.01).However，APC expression is lower in gastric carcinoma than that in normal tissue (53.33% vs. 91.11％). There is marked significance likewise（P<0.01）.The co-expression (Wnt pathway is activated，Wnt+) rate of Wnt1，β-catenin and cyclin D1 is 44.44％，which is much higher than that in normal tissue（P<0.01）. Conclusion Wnt1-β-catenin-APC-cyclinD1 signal pathway is abnormal expressed in gastric carcinoma genesis.
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    ZUO Lian-fu

    • 1.Department of Pathology，The Second Affiliated Hospital，Hebei North University，Zhangjiakou 075100，China；2.Department of Dermatology，The 251st Hospital of Chinese PLA;3.Institute of Oncology of The Fourth Affiliated Hospital，Hebei Medical University

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