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MA Xiang-tao, YU Li-wei, WANG Shan, DU Ru-yu, CUI Zhi-rong. Molecular Mechanisms Involved in Regulation of Proliferation and Apoptosis by Stat5 Antisense Oligonucleotide and AG490 in Colon Cancer Cells[J]. Cancer Research on Prevention and Treatment, 2006, 33(12): 883-886. DOI: 10.3971/j.issn.1000-8578.355
Citation: MA Xiang-tao, YU Li-wei, WANG Shan, DU Ru-yu, CUI Zhi-rong. Molecular Mechanisms Involved in Regulation of Proliferation and Apoptosis by Stat5 Antisense Oligonucleotide and AG490 in Colon Cancer Cells[J]. Cancer Research on Prevention and Treatment, 2006, 33(12): 883-886. DOI: 10.3971/j.issn.1000-8578.355
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Molecular Mechanisms Involved in Regulation of Proliferation and Apoptosis by Stat5 Antisense Oligonucleotide and AG490 in Colon Cancer Cells

  • 1.Department of Surgery; Beijing Haidian Hospital; Beijing 100080; China; 2.Department of Surgery and Division of Surgical Oncology; Peking University People's Hospital

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  • Corresponding author:

    MA Xiang-tao

  • Received Date: November 23, 2005
  • Revised Date: February 08, 2006
    Abstract
  • Objective In this study, we show that inhibition of the Stat5 signaling pathway using Stat5 AS-ON and AG490 significantly suppress the growth of colon cancer cell lines harboring constitutive active Stat5. Methods Stat5 AS-ON, AG490, or Stat5 AS-ON+AG490 was added into culture media, followed by MTT assay, the absorption value was measured and the growth curve was drawn; western blot analysis was performed on colon cancer cell lines; flow cytometry was applied to analyze the cell cycle and apoptosis. Result...
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    CUI Zhi-rong

    • 1.Department of Surgery; Beijing Haidian Hospital; Beijing 100080; China; 2.Department of Surgery and Division of Surgical Oncology; Peking University People's Hospital

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