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KUANG Xinhong, WEI Xiaohui, SUN Li, YUAN Shengtao. Progress on Relationship Between Posttranslational Modification Enzymes of Collagen and Tumor[J]. Cancer Research on Prevention and Treatment, 2016, 43(12): 1085-1089. DOI: 10.3971/j.issn.1000-8578.2016.12.016
Citation: KUANG Xinhong, WEI Xiaohui, SUN Li, YUAN Shengtao. Progress on Relationship Between Posttranslational Modification Enzymes of Collagen and Tumor[J]. Cancer Research on Prevention and Treatment, 2016, 43(12): 1085-1089. DOI: 10.3971/j.issn.1000-8578.2016.12.016
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Progress on Relationship Between Posttranslational Modification Enzymes of Collagen and Tumor

  • Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing 211100, China

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  • Corresponding author:

    YUAN Shengtao, E-mail:13914798635@163.com

  • Received Date: April 19, 2016
  • Revised Date: August 04, 2016
  • Available Online: February 04, 2024
    Graphical Abstract
    • Abstract

  • The deposition and stiffness of collagen promote tumor progression. As one of the processes in collagen biosynthesis, post-translation modifying of collagen is critical for collagenic stability. Three key enzymes catalyze collagen modification, such as prolyl-4-hydroxylase(P4H), lysyl hydroxylase(LH) and lysyl oxidase(LOX). Studies indicated that high levels of these enzymes could promote the initiation, the development, the invasiveness and the metastasis of tumor by inducing collagen remodeling and deposition. What’s more, it suggested that these enzymes may be potential targets for cancer therapy. In this review, we will focus on the basic characteristics of these enzymes and their associations with tumor progression.

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