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HE Ze-ming, MEI Jing-feng, QIN Shu-kui, HUANG Yong, CHEN Ying-xia. Clinical Study on Gemcitabine Combination with Cisplatin Therapy for Recurrent Advanced Head and Neck Cancer[J]. Cancer Research on Prevention and Treatment, 2005, 32(12): 790-791. DOI: 10.3971/j.issn.1000-8578.1538
Citation: HE Ze-ming, MEI Jing-feng, QIN Shu-kui, HUANG Yong, CHEN Ying-xia. Clinical Study on Gemcitabine Combination with Cisplatin Therapy for Recurrent Advanced Head and Neck Cancer[J]. Cancer Research on Prevention and Treatment, 2005, 32(12): 790-791. DOI: 10.3971/j.issn.1000-8578.1538
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Clinical Study on Gemcitabine Combination with Cisplatin Therapy for Recurrent Advanced Head and Neck Cancer

  • Oncology Center of PLA 81st Hospital, Nanjing 210002, China

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  • Corresponding author:

    HE Ze-ming

  • Received Date: June 23, 2004
  • Revised Date: October 05, 2005
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    • Abstract
  • Objective 　To evaluate the efficacy and toxicity of Gemcitabine ( GEM) combination with cisplatin (CDDP) treatment in the recurrent advanced head and neck cancer. Methods 　Twenty-seven patients of recurrent advanced head and neck cancer were treated. The treatment schedule was consisting of GEM 1 000mg/ m2 iv, dl, d8 and CDDP 60mg/ m 2/ cycle iv (divided into dl～5) . Cycles repeated for 21 days.All patient s received over 2 cycles of chemotherapy, median 3. 52 cycles. Results 　The overall response rate was 29. 63 % (1 complete response and 7 partial response were observed in 27 patients) . The median response duration was 4. 4 months. The median survival period was 9 months. The dose-limiting toxicity was mainly hematologic. Neut ropenia was the most frequent side-effect (85. 18 % of patient s ; grade 3～4 in 22. 22 %) . Conclusion 　The GEM and CDDP combination has a palliative role in patient s with recurrent advanced head and neck cancer.
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