| Citation: |
SUN Ying, LI Zhiming, KANG Ning, WANG Wenwen, WANG Aili, LI Tong. Clinical Study on Treatment of Bone Metastasis from Breast Cancer with Method of "Jian Pi Yi Qi Yang Xue Zhi Tong"[J]. Cancer Research on Prevention and Treatment, 2024, 51(4): 259-264. DOI: 10.3971/j.issn.1000-8578.2024.23.1126
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To explore the therapeutic effect of "jian pi yi qi yang xue zhi tong" for treating bone metastasis of breast cancer and the clinical effect of improving pain symptoms.
A total of 80 patients with bone metastases from breast cancer were admitted. They were randomly divided into an observation group and a control group according to the random-number-table method. The control group was treated with zoledronic acid, whereas the observation group was treated with jian pi yi qi yang xue zhi tong prescriptions based on the control group. We compared the differences in the effects of different treatment plans on patients' pain symptoms, physical condition, and quality of life, as well as TNF-α, IL-6, and CRP levels.
No significant difference was found in pain scores, physical condition scores, sleep quality scores, and quality of life scores, as well as CRP, IL-6, and TNF-α levels between the two groups of patients before treatment (all P > 0.05). At one, two, and four months after treatment, the pain scores of both groups of patients decreased, with the observation group having lower scores than the control group (P < 0.05). The total pain-relief rate of the observation group was higher than that of the control group (P < 0.05). After treatment, the sleep quality scores and the levels of CRP, IL-6, and TNF-α decreased, with the observation group having lower values than the control group (P < 0.05). The physical condition scores and the quality of life scores of both groups improved, with the observation group having higher values than the control group (P < 0.05).
In patients with bone metastases from breast cancer, oral treatment with jian pi yi qi yang xue zhi tong prescription has a significant effect. It substantially improves the pain symptoms, enhances the quality of sleep and life of patients, and reduces the levels of CRP, IL-6, and TNF-α.
Competing interests: The authors declare that they have no competing interests.
| [1] |
Zajączkowska R, Kocot-Kępska M, Leppert W, et al. Bone Pain in Cancer Patients: Mechanisms and Current Treatment[J]. Int J Mol Sci, 2019, 20(23): 6047. doi: 10.3390/ijms20236047
|
| [2] |
尤鸿吉, 李心歆, 周丽明, 等. 乳腺癌术后骨转移的相关临床危险因素分析[J]. 广州医科大学学报, 2022, 50(1): 39-45. https://www.cnki.com.cn/Article/CJFDTOTAL-GZXI202201006.htm
You HJ, Li XX, Zhou LM, et al. Clinical risk factors related to bone metastasis after breast cancer surgery[J]. Guangzhou Yi Ke Da Xue Xue Bao, 2022, 50(1): 39-45. https://www.cnki.com.cn/Article/CJFDTOTAL-GZXI202201006.htm
|
| [3] |
徐丹, 冷冰. 唑来膦酸预防高危乳腺癌患者骨转移的效果观察[J]. 中国地方病防治杂志, 2019, 34(4): 442-443. https://www.cnki.com.cn/Article/CJFDTOTAL-DYBF201904038.htm
Xu D, Leng B. Effect of zoledronic acid on preventing bone metastasis in high-risk patients with breast cancer[J]. Zhongguo Di Fang Bing Fang Zhi Za Zhi, 2019, 34(4): 442-443. https://www.cnki.com.cn/Article/CJFDTOTAL-DYBF201904038.htm
|
| [4] |
孔祥双, 郭光霞, 王连英, 等. 基层医院重度骨质疏松症病人唑来膦酸静脉给药不良反应观察及护理[J]. 护理研究, 2023, 37(17): 3226-3228. https://www.cnki.com.cn/Article/CJFDTOTAL-SXHZ202317035.htm
Kong XH, Guo GX, Wang LY, et al. Observation and nursing of adverse reactions of zoledronic acid intravenous administration in patients with severe osteoporosis in primary hospital[J]. Hu Li Yan Jiu, 2023, 37(17): 3226-3228. https://www.cnki.com.cn/Article/CJFDTOTAL-SXHZ202317035.htm
|
| [5] |
许继升, 宋爱莉, 浦冬青, 等. 名老中医宋爱莉治疗乳腺癌骨转移用药规律分析[J]. 中国医药导报, 2023, 20(9): 131-134, 143. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202309044.htm
Xu JS, Song AL, Pu DQ, et al. Analysis of medication rule of famous old traditional Chinese medicine doctor Song Aili in the treatment of breast cancer bone metastasis[J]. Zhongguo Yi Yao Dao Bao, 2023, 20(9): 131-134, 143. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202309044.htm
|
| [6] |
朱蓉, 郭雪斌, 杨满英, 等. 补肾活血汤对乳腺癌骨转移模型裸鼠Bax/Bcl-2及cleaved Caspase-3蛋白表达的影响[J]. 中国实验方剂学杂志, 2023, 29(8): 133-141. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202308016.htm
Zhu R, Guo XB, Yang MY, et al. Effects of Bushen Huoxuetang on expression of Bax/Bcl-2 and cleaved Caspase-3 in nude mice with bone metastasis of breast cancer[J]. Zhongguo Shi Yan Fang Ji Xue Za Zhi, 2023, 29(8): 133-141. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202308016.htm
|
| [7] |
殷玉琨, 陈佳阳, 刘丽星, 等. 益肾祛痛颗粒抑制乳腺癌骨转移及对骨桥蛋白表达的影响[J]. 中华中医药学刊, 2023, 41(3): 26-29, 后插3-5. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202303006.htm
Yin YK, Chen JY, Liu LX, et al. Effect of Yishen qutong granule on inhibitting bone metastasis and expression of osteopontin in breast cancer[J]. Zhonghua Zhong Yi Yao Xue Kan, 2023, 41(3): 26-29, back insert 3-5. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202303006.htm
|
| [8] |
中国抗癌协会乳腺癌专业委员会. 中国抗癌协会乳腺癌诊治指南与规范(2021年版)[J]. 中国癌症杂志, 2021, 31(10): 954-1040. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGAZ202312004.htm
Breast Cancer Professional Committee of Chinese Anti-Cancer Association. Guidelines and Norms for Diagnosis and Treatment of breast cancer of Chinese Anticancer Association (2021 edition)[J]. Zhongguo Ai Zheng Za Zhi, 2021, 31(10): 954-1040. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGAZ202312004.htm
|
| [9] |
于世英, 江泽飞, 张力, 等. 恶性肿瘤骨转移及骨相关疾病临床诊疗中国专家共识[J]. 中德临床肿瘤学杂志(英文版), 2010, 9(1): 1-12. https://xuewen.cnki.net/CCND-YIYA20100608B032.html
Yu SY, Jiang ZF, Zhang L, et al. Chinese expert consensus statement on clinical diagnosis and treatment of malignant tumor bone metastasis and bone-related diseases[J]. Zhong De Lin Chuang Zhong Liu Xue Za Zhi (Ying Wen Ban), 2010, 9(1): 1-12. https://xuewen.cnki.net/CCND-YIYA20100608B032.html
|
| [10] |
孔祥鸣. 癌痛规范化治疗与临床实践[M]. 上海: 上海科学技术出版社, 2013: 27-45.
Kong XM. Standardized treatment and clinical practice of cancer pain[M]. Shanghai: Shanghai Science and Technology Press, 2013: 27-45.
|
| [11] |
McNair KM, Zeitlin D, Slivka AM, et al. Translation of Karnofsky Performance Status (KPS) for use in inpatient cancer rehabilitation[J]. PM R, 2023, 15(1): 65-68. doi: 10.1002/pmrj.12741
|
| [12] |
刘志喜, 石倩萍, 杨洪霞, 等. 匹兹堡睡眠质量指数量表在护理人群中的信效度评价[J]. 汕头大学医学院学报, 2020, 33(3): 173-176. https://www.cnki.com.cn/Article/CJFDTOTAL-STDY202003011.htm
Liu ZX, Shi QP, Yang HX, et al. Reliability and validity evaluation of Pittsburgh Sleep Quality Index in nursing population[J]. Shantou Da Xue Yi Xue Yuan Xue Bao, 2020, 33(3): 173-176. https://www.cnki.com.cn/Article/CJFDTOTAL-STDY202003011.htm
|
| [13] |
Poquet N, Lin C. The Brief Pain Inventory (BPI)[J]. J Physiother, 2016, 62(1): 52. doi: 10.1016/j.jphys.2015.07.001
|
| [14] |
陈音, 邹庆芳, 邵宏斌, 等. 局部放疗联合注射用因卡膦酸二钠对原发性肝癌骨转移患者的疗效和安全性分析[J]. 肿瘤综合治疗电子杂志, 2022, 8(4): 45-50. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLZD202204008.htm
Chen Y, Zou QF, Shao HB, et al. Efficacy and safety of local radiotherapy combined with infadronate disodium for injection in patients with bone metastasis of primary liver cancer[J]. Zhong Liu Zong He Zhi Liao Dian Zi Za Zhi, 2022, 8(4): 45-50. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLZD202204008.htm
|
| [15] |
李中梨, 王剑锋, 张文学. 因卡膦酸二钠与唑来膦酸治疗癌性骨转移性疼痛的疗效比较[J]. 肿瘤综合治疗电子杂志, 2020, 6(1): 115-117. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLZD202001016.htm
Li ZL, Wang JF, Zhang WX. The efficacy of incadronate disodium and zoledronic acid in the treatment of cancerous bone metastatasis pain[J]. Zhong Liu Zong He Zhi Liao Dian Zi Za Zhi, 2020, 6(1): 115-117. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLZD202001016.htm
|
| [16] |
南云鑫, 张磊, 陈洪炀, 等. 李佩文运用风药开玄治疗乳腺癌骨转移经验[J]. 中医药导报, 2023, 29(3): 224-227. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202303045.htm
Nan YX, Zhang L, Chen HY, et al. Li Peiwen's experience in treating bone metastases of breast cancer with wind-induced medicine[J]. Zhong Yi Yao Dao Bao, 2023, 29(3): 224-227. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202303045.htm
|
| [17] |
黄倩芸, 叶丽红. 章永红教授治疗乳腺癌用药分析[J]. 天津中医药大学学报, 2018, 37(5): 357-360. https://www.cnki.com.cn/Article/CJFDTOTAL-TZYY201805002.htm
Huang QY, Ye LH. The analysis of Professor Zhang Yonghong's dtraditional Chinese medicin utilization regulation for treating breast cancer[J]. Tianjin Zhong Yi Yao Da Xue Xue Bao, 2018, 37(5): 357-360. https://www.cnki.com.cn/Article/CJFDTOTAL-TZYY201805002.htm
|
| [18] |
梅莎莎, 宋恩峰. 健脾生血颗粒治疗气血两虚型癌因性疲乏的临床疗效研究[J]. 世界中医药, 2022, 17(18): 2623-2627. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZA202218016.htm
Me SS, Song EF. Clinical observation on Jianpi Shengxue Granules in the treatment of cancer-related fatigue of patients with syndrome of both Qi and blood deficiency[J]. Shi Jie Zhong Yi Yao, 2022, 17(18): 2623-2627. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZA202218016.htm
|
| [19] |
曲小雨, 范小斌, 牛志莹, 等. 骨感染患者血清炎性因子水平分析[J]. 中华医院感染学杂志, 2016, 26(15): 3500-3502. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201615051.htm
Qu XY, Fan XB, Niu ZY, et al. Serum inflammatory factors level analysis in patients with bone infection[J]. Zhonghua Yi Yuan Gan Ran Xue Za Zhi, 2016, 26(15): 3500-3502. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201615051.htm
|
| [20] |
王展, 宋玉鑫, 钱耀文. 大骨节病患者全膝关节置换术后炎症因子表达与疼痛程度相关性分析[J]. 中华地方病学杂志, 2019, 38(12): 955-958.
Wang Z, Song YX, Qian YW. Correlation analysis of inflammatory factors expression and pain degree with Kashin-Beck disease after total knee arthroplasty[J]. Zhonghua Di Fang Bing Xue Za Zhi, 2019, 38(12): 955-958.
|
| [21] |
黄少烁, 李嘉程, 骆帝, 等. 黄芪甲苷可减轻白细胞介素1β诱导软骨细胞的炎症反应[J]. 中国组织工程研究, 2023, 27(26): 4113-4119. https://www.cnki.com.cn/Article/CJFDTOTAL-XDKF202326003.htm
Huang SS, Li JC, Luo D, et al. Astragaloside Ⅳ can reduce the interleukin-1beta-induced chondrocyte inflammation[J]. Zhongguo Zu Zhi Gong Cheng Yan Jiu, 2023, 27(26): 4113-4119. https://www.cnki.com.cn/Article/CJFDTOTAL-XDKF202326003.htm
|
| [22] |
兰宝恒, 吴泽青. 柴胡的化学成分及药理作用研究进展[J]. 新乡医学院学报, 2023, 40(2): 174-180. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYX202302015.htm
Lan BH, Wu ZQ. Research progress on chemical constituents and pharmacological action of Bupleurum[J]. Xinxiang Yi Xue Yuan Xue Bao, 2023, 40(2): 174-180. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYX202302015.htm
|
| [23] |
魏巍, 王冰瑶. 莪术及其主要成分的药理作用研究进展[J]. 药物评价研究, 2022, 45(10): 2154-2160. https://www.cnki.com.cn/Article/CJFDTOTAL-YWPJ202210029.htm
Wei W, Wang BY. Research progress on pharmacological effects of Curcumae Rhinzoma and its main compositions[J]. Yao Wu Ping Jia Yan Jiu, 2022, 45(10): 2154-2160. https://www.cnki.com.cn/Article/CJFDTOTAL-YWPJ202210029.htm
|
| [24] |
高明旭. 白芍总苷对类风湿关节炎的治疗作用研究[D]. 山东: 青岛大学, 2022.
Gao MX. Study on the therapeutic effect of total glucosides of Paeony on rheumatoid arthritis[D]. Shandong: Qingdao University, 2022.
|
| [25] |
郝腾腾, 袁菊花, 吴煜, 等. 威灵仙治疗癌性疼痛"成分-靶点"网络机制探索[J]. 中医肿瘤学杂志, 2022, 4(6): 19-27. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYZL202206004.htm
Hao TT, Yuan JH, Wu Y, et al. Component-target Pharmacological Mechanism of Radix Clematidis in Treating Cancer Pain Based on Network Pharmacology[J]. Zhong Yi Zhong Liu Xue Za Zhi, 2022, 4(6): 19-27. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYZL202206004.htm
|
| [26] |
任小瑞, 张恩欣, 吴红洁. 中药全蝎抗肿瘤的研究进展[J]. 中华中医药学刊, 2021, 39(11): 90-93. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202111024.htm
Ren XR, Zhang EX, Wu HJ. Research progress on anti-cancer Chinese traditional medicine Quanxie(Scorpion)[J]. Zhonghua Zhong Yi Yao Xue Kan, 2021, 39(11): 90-93. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202111024.htm
|
| [27] |
吴杰, 曹马怡洁, 彭颖, 等. 生、醋黄丝郁金治疗"肝郁气滞"型痛经大鼠的药效比较研究[J]. 中国中药杂志, 2023, 48(13): 3498-3507. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY202313024.htm
Wu J, Cao MYJ, Peng Y, et al. Effect of processing with vinegar on efficacy of Curcuma longa in treatment dysmenorrhea in rats with syndrome of liver depression and Qi Stagnation[J]. Zhongguo Zhong Yi Yao Za Zhi, 2023, 48(13): 3498-3507. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY202313024.htm
|
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| |
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庄君，卢彩鑫，谢翠英. Munro量表分级管理对胃癌术后患者压疮预防及康复效率的影响. 中国病案. 2022(03): 101-103 .
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| 4. |
林鹏航，林春霖，王琴，何若凡，陈辉，黄永建，杨树钢，叶建新，朱广伟. 胃癌D2根治术后短期并发症对患者远期生存率的影响. 肿瘤防治研究. 2021(06): 625-630 .
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