Research Progress of Anti-cancer Drug Delivery System Based on Silica Nanoparticles

ZHENG Weibin; ZHANG Boya; YIN Xiaochen; WANG Xin; ZHAO Qinjian

doi:10.3971/j.issn.1000-8578.2020.19.0785

Cancer Research on Prevention and Treatment > 2020 > 47(2): 135-140. > DOI: 10.3971/j.issn.1000-8578.2020.19.0785

ZHENG Weibin, ZHANG Boya, YIN Xiaochen, WANG Xin, ZHAO Qinjian. Research Progress of Anti-cancer Drug Delivery System Based on Silica Nanoparticles[J]. Cancer Research on Prevention and Treatment, 2020, 47(2): 135-140. DOI: 10.3971/j.issn.1000-8578.2020.19.0785

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Research Progress of Anti-cancer Drug Delivery System Based on Silica Nanoparticles

1.
National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen 361102, China
2.
School of Life Science, Xiamen University, Xiamen 361102, China

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Corresponding author:
ZHAO Qinjian, E-mail:qinjian_zhao@xmu.edu.cn
Received Date: June 13, 2019
Revised Date: September 03, 2019
Available Online: January 12, 2024

Abstract

Abstract

In recent years, more and more attention has been paid to the development of cancer diagnosis and treatment, including nanoparticles-based methods. Silica nanoparticles show great potential in the field of tumor diagnosis and treatment because of its unique physical and chemical properties. The drug delivery system based on SiO₂ NPs can passively or actively target tumor tissues, and controllably release of cytotoxic drug at the tumor tissue by responding to different stimuli modes. It can effectively increase the concentration of anti-tumor drugs at the tumor site and improve treatment efficiency. In addition, SiO₂ NPs can be used for tumor tissue localization and drug tracking by loading contrast agent to achieve the function of biological imaging. In this way, more efficient anti-tumor treatment can be achieved. In this paper, we introduced the preparation methods of SiO₂ NPs and review the research progress of SiO₂ NPs in targeted drug delivery system and biological imaging field.
- Silica nanoparticles,
- Anticancer,
- Drug delivery system,
- Stimuli response,
- Biological imaging

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References (53)

References

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Corresponding author: ZHAO Qinjian, qinjian_zhao@xmu.edu.cn

1.
National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen 361102, China

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Research Progress of Anti-cancer Drug Delivery System Based on Silica Nanoparticles