Relation Between Albumin to Fibrinogen Ratio and Overall Survival of Breast Cancer

ZHENG Lihua; LIU Feng; LI Wei; ZHAO Yaheng; YANG Yan; WU Shang; LIU Yunjiang

doi:10.3971/j.issn.1000-8578.2020.19.0684

Cancer Research on Prevention and Treatment > 2020 > 47(2): 102-107. > DOI: 10.3971/j.issn.1000-8578.2020.19.0684

ZHENG Lihua, LIU Feng, LI Wei, ZHAO Yaheng, YANG Yan, WU Shang, LIU Yunjiang. Relation Between Albumin to Fibrinogen Ratio and Overall Survival of Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2020, 47(2): 102-107. DOI: 10.3971/j.issn.1000-8578.2020.19.0684

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Relation Between Albumin to Fibrinogen Ratio and Overall Survival of Breast Cancer

1.
Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang 050011, China
2.
Department of Breast Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

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Corresponding author:
LIU Yunjiang,E-mail: lyj818326@outlook.com
Received Date: May 26, 2019
Revised Date: August 27, 2019
Available Online: January 12, 2024

Abstract

Abstract

Objective
To investigate the prognostic significance of albumin to fibrinogen ratio (AFR) in breast infiltrating ductal carcinoma.
Methods
We collected 230 blood and clinical data of breast invasive ductal carcinoma admitted to the Breast Center of the Fourth Hospital of Hebei Medical University from January 2009 to April 2012. A retrospective study was conducted to collect fibrinogen and albumin indicators from preoperative patients. Survival analysis was performed using Kaplan-Meier method and Cox proportional regression risk model to explore the relation between AFR expression and prognosis. AFR was divided into two groups by two classifications: AFR < 13.1 and AFR≥13.1. The univariate and multivariate analyses were used to analysis the relation between AFR and patients' survival, then a prognosis model was established.
Results
The survival rate of patients was reduced when AFR≥13.1. In the multivariate analysis, the variables with P < 0.05 were used to create a model. AFR, white blood cell (WBC), estrogen receptor(ER) or progesterone receptor (PR), TNM, nuclear grading, p53, vascular tumor thrombus and other OS indicators were used to predict the survival time of patients. The receiver operating characteristic(ROC) curve area was 0.882.
Conclusion
Low AFR expression is an independent prognostic factor for breast cancer. Seven indicators, including AFR, WBC, ER/PR, TNM, nuclear grading, p53 and vascular tumor thrombus, were used to create an OS predictive model, which could predict the prognosis of breast infiltrating ductal carcinoma patients.
- Albumin to fibrinogen ratio(AFR),
- Invasive ductal carcinoma of the breast,
- Overall survival

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References (18)

References

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Corresponding author: LIU Yunjiang, lyj818326@outlook.com

2.
Department of Breast Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

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Relation Between Albumin to Fibrinogen Ratio and Overall Survival of Breast Cancer