| Citation: |
LI Wei, SUN Mingyuan, LIU Yuntao, GONG Benfa, ZHANG Guangji, WEI Shuning, QIU Shaowei, MI Yingchang, WANG Jianxiang. High-doses Granulocyte Colony-stimulating Factor (G-CSF) Benefit Elderly Patients with Acute Myeloid Leukemia[J]. Cancer Research on Prevention and Treatment, 2018, 45(5): 329-332. DOI: 10.3971/j.issn.1000-8578.2018.17.1096
|
To analyze the effects of high-dose (> 5 μg/kg) and standard-dose (5 μg/kg) granulocyte colony-stimulating factor (G-CSF) on infection and blood transfusion in elderly patients with acute myeloid leukemia (AML) during chemotherapy.
During the 273 cycles of chemotherapy, 82 elderly patients with AML were treated with two doses of G-CSF. The use of antibiotics and antifungal agents, fever days, the degree of fever, neutropenia time and the blood transfusion were analyzed retrospectively.
In 273 cycles of chemotherapy, there were 223(81.7%) times of concurrent infection, 11(13.4%) patients were discontinued due to the infection; In standard treatment group 2(2.3%) patients died during induction treatment. Subgroup analysis showed the high-dose group significantly shortened the neutropenia and fever time and decreased the use of antifungal agents.
High-dose G-CSF could improve the safety and tolerability of chemotherapy in elderly patients with AML.
| [1] |
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012[J]. CA Cancer J Clin, 2012, 62(1): 10-29. doi: 10.3322/caac.20138
|
| [2] |
Lewis DR, Chen HS, Midthune DN, et al. Early estimates of SEER cancer incidence for 2012: Approaches, opportunities, and cautions for obtaining preliminary estimates of cancer incidence [J]. Cancer, 2015, 121(12): 2053-62. doi: 10.1002/cncr.v121.12
|
| [3] |
Klepin HD. Elderly acute myeloid leukemia: Assessing risk[J]. Curr Hematol Malig Rep, 2015, 10(2): 118-25. doi: 10.1007/s11899-015-0257-2
|
| [4] |
Tsitsikas DA, Morin A, Araf S, et al. Impact of the revised (2008) EORTC/MSG definitions for invasive fungal disease on the rates of diagnosis of invasive aspergillosis[J]. Med Mycol, 2012, 50(5): 538-42. doi: 10.3109/13693786.2011.630040
|
| [5] |
Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America[J]. Clin Infect Dis, 2011, 52(4): e56-93. doi: 10.1093/cid/cir073
|
| [6] |
Othus M, Kantarjian H, Petersdorf S, et al. Declining rates of treatment-related mortality in patients with newly diagnosed AML given 'intense' induction regimens: a report from SWOG and MD Anderson[J]. Leukemia, 2014, 28(2): 289-92. doi: 10.1038/leu.2013.176
|
| [7] |
Tawfik B, Pardee T, Isom S, et al. Comorbidity, age and mortality among adults treated intensively for acute myeloid leukemia (AML)[J]. J Geriatr Oncol, 2016, 7(1): 24-31. doi: 10.1016/j.jgo.2015.10.182
|
| [8] |
Kuderer NM, Dale DC, Crawford J, et al. Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients[J]. Cancer, 2006, 106(10): 2258-66. doi: 10.1002/(ISSN)1097-0142
|
| [9] |
Lyman GH, Dale DC, Wolff DA, et al. Acute myeloid leukemia or myelodysplastic syndrome in randomized controlled clinical trials of cancer chemotherapy with granulocyte colony-stimulating factor: a systematic review[J]. J Clin Oncol, 2010, 28(17): 2914-24. doi: 10.1200/JCO.2009.25.8723
|
| [10] |
Bennett CL, Djulbegovic B, Norris LB, et al. Colonystimulating factors for febrile neutropenia during cancer therapy[J]. N Engl J Med, 2013, 368(12): 1131-9. doi: 10.1056/NEJMct1210890
|
| [11] |
Tigue CC, McKoy JM, Evens AM, et al. Granulocyte-colony stimulating factor administration to healthy individuals and persons with chronic neutropenia or cancer: an overview of safety considerations from the Research on Adverse Drug Events and Reports project[J]. Bone Marrow Transplant, 2007, 40(3): 185-92. doi: 10.1038/sj.bmt.1705722
|
| [12] |
D'Souza A, Jaiyesimi I, Trainor L, et al. Granulocyte colony-stimul-ating factor administration: adverse events[J]. Transfus Med Rev, 2008, 22(4): 280-90. doi: 10.1016/j.tmrv.2008.05.005
|
| [1] | SHEN Zhaohua, ZENG Dongfeng, KONG Peiyan. Recent Advances of G-CSF Priming in Chemotherapy for Refractory or Recurrent Acute Leukemia[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 526-530. DOI: 10.3971/j.issn.1000-8578.2015.05.023 |
| [3] | YANG Li-xin, SHAN Li, WU Li. Clinical Analysis of Nosocomial Pulmonary Fungal Infection in Patients with Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2009, 36(11): 957-960. DOI: 10.3971/j.issn.1000-8578.2009.11.015 |
| [4] | DI Li-jun, REN Jun, YU Jing, SONG Guo-hong, ZHANG Chun-rong, MENG Song-niang, CHE Li, FANG Jian. High-dose Docetaxel with Granulocyte Colony-stimulating Factor for Mobilization of Autologous Peripheral Blood Stem/Progenitor Cells in Patients with Malignant Solid Tumors[J]. Cancer Research on Prevention and Treatment, 2008, 35(04): 275-277. DOI: 10.3971/j.issn.1000-8578.1539 |
| [5] | GU Yan, ZHENG Ling, WU Jian-rong, WANG Xiao-yu, ZHANG Hong-bin, ZHU Jun-chen, JIANG Jia-ming. Comparison between Combination of G-CSF and GM-CSF in Patients With Arrest of Bone Marrow Caused by Chemotherapy[J]. Cancer Research on Prevention and Treatment, 2007, 34(02): 146-148. DOI: 10.3971/j.issn.1000-8578.1546 |
| [6] | HANG Yong-lun, CAI Mei-zhu, YANG Ping. Practical Use Four Acute Phase Proteins Measurement in Patients with Cancer[J]. Cancer Research on Prevention and Treatment, 2005, 32(04): 229-230. DOI: 10.3971/j.issn.1000-8578.1669 |
| [7] | HU Ke, CHEN Li, LIU Zhen-lian. Relationship of human papillomavirus types 16 and 18 infection and p53 gene mutation in lung squamous cell carcinoma[J]. Cancer Research on Prevention and Treatment, 2002, 29(02): 116-117. DOI: 10.3971/j.issn.1000-8578.934 |
| [8] | GONG Li-zhong, ZHANG Mao-hong, XU Cong-gao. The Changes of Number and Activity of Natural Killer Cells during Mobilization by Cyclophospamide and G-CSF[J]. Cancer Research on Prevention and Treatment, 2001, 28(05): 369-371. DOI: 10.3971/j.issn.1000-8578.980 |
| [9] | Ni Zhiquan. A Study on HBV2 Infection of Serum of Primary Liver Cancer in Qidong[J]. Cancer Research on Prevention and Treatment, 1997, 24(6): 340-341. |
| [10] | Lu jiasun, . Analysis in the infected HBV in some patients with malignant tumor[J]. Cancer Research on Prevention and Treatment, 1996, 23(2): 93-94. |
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号
Supported by: Beijing Renhe Information Technology Co., Ltd. 
DownLoad: