| Citation: |
TAN Yi, LIU Yan, SONG Yuwei, CHEN Qiufang, TAN Guoqiang, GUI Xiujuan, LIN Shaoqiang. Prognostic Value of Circulating Tumor Cells for Metastatic Prostate Cancer: A Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2016, 43(9): 783-788. DOI: 10.3971/j.issn.1000-8578.2016.09.011
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To systematically review the prognostic value of circulating tumor cells(CTCs) for metastatic prostate cancer patients by Meta-analysis.
We electronically searched PubMed, EMbase, Cochrane Library, CNKI and CBM for collecting the studies about the prognostic relevance of CTCs in the peripheral blood of Gleason score 0-10th metastatic prostate cancer patients. The observation endpoint was the overall survival(OS). Review Manager 5.3 was used for this analysis.
A total of 10 studies involving 1 137 patients of metastatic prostate cancer were eligible for the final analyses. The results of Meta-analysis showed that the presence of CTCs was associated with OS(HR=2.47, 95%CI: 2.02-3.02, P＜0.00001). According to the subgroup analysis by the detection time and the detection method, CTCs positive group show the poor prognosis than CTCs negative group patients. CTCs positive group showed a significantly positive correlation with the Gleason score of prostate cancer (OR=2.23, 95%CI: 1.41-3.53, P＜0.04), rather than PSA or extra bone metastasis.
CTCs is an adverse prognostic factor for metastatic prostate cancer patients, which is not significantly influenced by the detection time and check method.
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