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ZHANG Cong, DAI Tianyang. Progress on miRNAs in Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 204-208. DOI: 10.3971/j.issn.1000-8578.2015.02.023
Citation: ZHANG Cong, DAI Tianyang. Progress on miRNAs in Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 204-208. DOI: 10.3971/j.issn.1000-8578.2015.02.023

Progress on miRNAs in Esophageal Squamous Cell Carcinoma

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  • Received Date: July 24, 2014
  • Revised Date: September 23, 2014
  • Esophageal squamous cell carcinoma(ESCC) is the major subtype of esophageal cancer(EC) in China. Although the molecular genetics of ESCC have been widely studied, the molecular mechanism of ESCC carcinogenesis has not been completely understood. microRNAs(miRNAs) are a class of small, endogenous, and non-protein-coding RNAs. They have a role in biological and pathological process, including cell differentiation, apoptosis, proliferation and metabolism. miRNAs have a potential role in ESCC pathogenesis through oncogenes or tumor suppressor genes. Recent years, some studies show that a substantial number of miRNAs are differentially expressed in esophageal cancer tissues. A better knowledge of the roles of miRNAs and their target genes in ESCC development may provide new avenues for the early detection, diagnosis, therapy, and prognosis of ESCC.
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