Association of HLA-E Gene Polymorphisms with Genetic Susceptibility to Breast Carcinoma

ZHOU Yan; WU Zhencun; CHENG Jianjun; JIA Tianjun

doi:10.3971/j.issn.1000-8578.2015.02.020

Cancer Research on Prevention and Treatment > 2015 > 42(02): 190-193. > DOI: 10.3971/j.issn.1000-8578.2015.02.020

ZHOU Yan, WU Zhencun, CHENG Jianjun, JIA Tianjun. Association of HLA-E Gene Polymorphisms with Genetic Susceptibility to Breast Carcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 190-193. DOI: 10.3971/j.issn.1000-8578.2015.02.020

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Association of HLA-E Gene Polymorphisms with Genetic Susceptibility to Breast Carcinoma

1.Department of Immunology, Hebei North University, Zhangjiakou 075000,China; 2.Laboratory Department, Maternal and Child Health Hospital of Zhangjiakou, Zhangjiakou 075000, China

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Received Date: February 19, 2014
Revised Date: September 16, 2014

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Abstract

Objective To investigate the association between HLA-E gene polymorphisms and genetic susceptibility of female breast carcinoma in Han Nationality in Zhangjiakou, China. Methods HLA-E typing was performed for 200 breast cancer patients and 114 healthy controls from Zhangjiakou area by polymerase chain reaction-sequence-specific priming (PCR-SSP). Results Two alleles of HLA-E could be detected, HLA-E*0101 and HLA-E*0103; simultaneously three genotypes were detected, namely HLA-E*0101/0101, HLA-E*0101/0103 and HLA-E*0103/0103. The frequencies of HLA-E*0103 allele and HLA-E*0103/HLA-E*0103 genotype were significant different between healthy controls and breast cancer patients(P＜0.01). The risk of breast cancer was significantly increased in HLA-E*0103/ HLA-E*0103 genotype(OR=2.05, P=0.004). Conclusion HLA-E gene polymorphisms are associated with the development of female breast cancer of the Han in Zhangjiakou, China; moreover, HLA-E*0103/ HLA-E*0103 genotype is probably the susceptible genotype.
- Human leukocyte antigen-E(HLA-E),
- Polymerase chain reaction-sequence-specific priming,
- Breast carcinoma,
- Polymorphisms

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