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LIU XiaoPing, DENG Wei, SU Jinjie, ZENG Xiangfu. Prognostic Value of VEGF-C and Podoplanin Expressions in Rectum Cancer Tissues with Lymph Node Metastasis in Elder Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 164-167. DOI: 10.3971/j.issn.1000-8578.2015.02.014
Citation: LIU XiaoPing, DENG Wei, SU Jinjie, ZENG Xiangfu. Prognostic Value of VEGF-C and Podoplanin Expressions in Rectum Cancer Tissues with Lymph Node Metastasis in Elder Patients[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 164-167. DOI: 10.3971/j.issn.1000-8578.2015.02.014
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Prognostic Value of VEGF-C and Podoplanin Expressions in Rectum Cancer Tissues with Lymph Node Metastasis in Elder Patients

  • Department of Gastrointestinal Surgery, The First Affiliated Hospital, Gannan Medical University, Ganzhou 341000, China

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  • Received Date: April 14, 2014
  • Revised Date: July 25, 2014
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    • Abstract
  • Objective To investigate the expressions of vascular endothelial growth factor C(VEGF-C) and Podoplanin in rectum cancer tissues with lymph node metastasis in elder patients and their relationship with the prognosis. Methods VEGF-C and Podoplanin expressions in rectum carcinoma tissues and the corresponding lymph node metastasis carcinoma tissues in elder patients were detected by immunohistochemical method. At the same time the postoperative follow-up of these patients were analyzed. Results The expression rates of VEGF-C and Podoplanin in rectum carcinoma tissues with lymph node metastasis were higher than those in primary carcinoma tissues. The expressions of VEGF-C and Podoplanin in rectum carcinoma tissues with lymph node metastasis in elder patients were higher than those without lymph node(P<0.05). The levels of VEGF-C and Podoplanin and lymph node metastasis were the key factors to influence the prognosis of rectum cancer in elder patients. Conclusion VEGF-C and Podoplanin are highly expressed in rectum cancer tissues with lymph node metastasis in elder patients and related with the prognosis of rectum cancer. Their combination could be used as the index for the prognosis of rectum cancer with lymph node metastasis in elder patients.
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    • References (11)
  • [1]
    Zeng ZM, Liu J, Xian XB. Expression and significance of VEGF-C in rectal adenocarcinoma of human[J]. Chongqing Yi Xue, 2011, 40 (5): 425-6, 429, cover3. [曾昭明, 刘杰, 先雄斌, 等. 人直肠 癌血管内皮生长因子-C的表达及其意义[J]. 重庆医学, 2011, 40 (5): 425-6, 429, 封3页.]
    [2]
    Pula B, Witkiewicz W, Dziegiel P, et al. Significance of podoplanin expression in cancer-associated fibroblasts: a comprehensive review[J]. Int J Oncol, 2013, 42(6): 1849-57.
    [3]
    Liu XP, Liao Q, Li Jian, et al. Significance of VEGF-C and LYVE-1 detection in lower rectal carcinoma[J]. Zhongguo Pu Tong Wai Ke Za Zhi, 2010,19(4):439-41. [刘晓平, 廖桥, 李剑, 等. 低位直肠癌VEGF-C及LYVE-1检测的意义[J]. 中国普通外科杂 志, 2010, 19(4): 439-41.]
    [4]
    Liu XP, Zhou XQ, Su JJ, et al. The relationship between lymphatic microvessel density and podoplanin expression in rectal cancer[J]. Zhongguo Pu Tong Wai Ke Za Zhi, 2012, 21(6): 693-5.[刘晓平, 周小青, 苏晋捷, 等.直肠癌微淋巴管密度与Podoplanin表达的 关系[J] 中国普通外科杂志, 2012, 21(6): 693-5.]
    [5]
    Singh A, Gautam KA, Dalela D, et al. Plasma vascular endothelial growth factors A and C in patients undergoing prostatic biopsy and TURP for suspected prostatic neoplasia[J]. Asian Pac J Cancer Prev, 2013, 14(3): 2053-8.
    [6]
    Martins SF, Garcia EA, Luz MA, et a1. Clinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer[J]. Cancer Genomics Proteomics, 2013, 10(2): 55-67.
    [7]
    Kigure W, Fujii T, Sutoh T, et al. The association of VEGFC expression with tumor lymphatic vessel density and lymph node metastasis in patients with gastric cancer and gastrointestinal stromal tumor[J]. Hepatogastroenterology, 2013, 60(122): 277-80.
    [8]
    Jia ZL, Chen X, Li EX. Clinical significance of VEGF-C expression and LVD detection in predicting the prognosis of stage Ⅱ postoperative colorectal cancer[J]. Xi’an Jiao Tong Da Xue Xue Bao(Yi Xue Ban), 2011, 32(1): 119-23. [贾宗良, 陈旭, 李恩孝. 血 管内皮生长因子C及淋巴管密度的表达对判定Ⅱ期结直肠癌预 后的意义[J],西安交通大学学报(医学版), 2011, 32(1): 119-23.]
    [9]
    Pula B, Wojnar A, Werynska B, et al. Impact of different tumour stroma assessment methods regarding podoplanin expression on clinical outcome in patients with invasive ductal breast carcinoma[J]. Anticancer Res, 2013, 33(4): 1447-55.
    [10]
    Ordóñez NG. Value of podoplanin as an immunohistochemical marker in tumor diagnosis: a review and update[J]. Appl Immunohistochem Mol Morphol, 2014, 22(5): 331-47.
    [11]
    Foschini MP, Leonardi E, Eusebi LH, et al. Podoplanin and E-cadherin expression in preoperative incisional biopsies of oral squamous cell carcinoma is related to lymph node metastases[J]. Int J Surg Pathol, 2013, 21(2): 133-41.
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