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HUANG Shaojun, WANG Jingjing, JIANG Hua, CAO Hongliang. Value of miR-155 Expression in Forecast of Recurrence or Metastasis and Its Correlation with Serum CEA Levels after Operation[J]. Cancer Research on Prevention and Treatment, 2014, 41(06): 606-609. DOI: 10.3971/j.issn.1000-8578.2014.06.021
Citation: HUANG Shaojun, WANG Jingjing, JIANG Hua, CAO Hongliang. Value of miR-155 Expression in Forecast of Recurrence or Metastasis and Its Correlation with Serum CEA Levels after Operation[J]. Cancer Research on Prevention and Treatment, 2014, 41(06): 606-609. DOI: 10.3971/j.issn.1000-8578.2014.06.021

Value of miR-155 Expression in Forecast of Recurrence or Metastasis and Its Correlation with Serum CEA Levels after Operation

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  • Received Date: May 29, 2013
  • Revised Date: November 13, 2013
  • Objective To analyze the correlation between miR-155 expression and serum CEA levels in colon carcinoma, and to explore its value in forecast of recurrence and metastasis after operation. Methods miR-155 expressions in 84 specimens of colon carcinoma and their matched adjacent tissues were examined by RT-PCR, and preoperative serum CEA levels were tested at the same time. The follow-up visit lasted for 2 years after operation and serum CEA levels were tested every two months. Results miR-155 expression was 4.03±2.95 in colon carcinoma, which was signifi cantly higher than that in adjacent normal tissues (P<0.05). miR-155 expression in colon carcinoma was signifi cantly and positively correlated with preoperative serum CEA levels(P<0.01). miR-155 expression in colon carcinoma was significantly and negatively correlated with the time of serum CEA re-increasing after operation(P<0.01). miR-155 expression in recurrence and metastasis group was signifi cantly higher than that in non-recurrence or metastasis group(P<0.05). The time of serum CEA re-increasing was significantly correlated with recurrence and metastasis after operation. Conclusion miR-155 expression is up-regulated obviously in colon carcinoma. Detection of miR-155 expression and serum CEA levels before and after operation together can offer more accurate information for diagnosis and prognosis of colon carcinoma, especially for recurrence and metastasis after operation.
  • [1]
    Saletti P,Cavalli F,et al. Metastatic colorectal cancer[J].Cancer Treat Rev,2006,32(7):557-71.
    [2]
    Cao HL,Huang SH,Liu AH, et al. Expression of miR-155 and its clinical signifi cance in tissues of colonic cancer[J].Zhonghua Xiao Hua Wai Ke Za Zhi,2013,12(6):440-2.[曹红亮,黄少军,刘爱华,等. miR-155在结肠癌组织中的表达及其临床意义[J].中华消化外 科杂志,2013,12(6):440-2.]
    [3]
    Zhong X,Coukos G,Zhang L.miRNAs in human cancer[J]. Methods Mol Boil,2012,822:295-306 .
    [4]
    Garzon R,Fabbri M,Cimmino A,et al.MicroRNA expression and function in cancer[J].Trends Mol Med, 2006,12(12):580-7.
    [5]
    Jemal A,Siegel R,Ward E,et al.Cancer statistics,2008[J].CA Cancer J Clin,2008,58(2):71-96.
    [6]
    Zheng SR,Gun GL,Zhang W, et al.Clinical signifi cance of miR- 15 5 expression in breast cancer and effects of miR-155 ASO on cell viabilit y and apoptosis[J].Oncol Rep,2012,27(4):1149-55 .
    [7]
    Qin AD,Zhou Y,Sheng MX,et al.Effects of M icroRNA-155 on the growth of human lung cancer cell line 95D in vitro[J].Zhongguo Fei Ai Za Zhi,201l,14(7):575-80.[秦安东,周涯,盛美霞,等. MicroRNA-155对人肺癌95D细胞生长的影响[J].中国肺癌杂 志,201l,14(7):575-80.]
    [8]
    Bakirtzi K,Hatziapostolou M,Karagiannides I,et al.Neurotensin signaling activates microRNAs-21 and -155 and Akt,promotes tumor growth in mice,and is in creased in human colon tumors[J]. Gastroenterology,2011,141(5):1749-61.
    [9]
    Ryu JK,Hong SM,Karikari CA,et al.Aberrant microRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma[J].Pancreatology,2010,10(1):66-73.
    [10]
    Xie Q,Chen X,Lu F,et al.Aberrant expression of microRNA 155 may accelerate cell proliferation by targeting sex-determining region Y box 6 in hepatocellular carcinoma[J].Cancer,2012,118(9): 24 31-42.
    [11]
    Greither T,Grochola LF,Udelnow A,et al.Elevated expression of microRNAs 155,203,210 and 222 in pancreatic tumors is associated with poorer survival[J].Int J Cancer,2010,126(1):73-80.
    [12]
    Wang XY,Wu MH,Liu F, et al.Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells[J]. Mol Cell Biochem,2010,345(1-2):283-90.
    [13]
    Kong W,Yang H,He L,et al.MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA[J].Mol Cell Biol,2008,28(22):6773-84.
    [14]
    Gironella M,Seux M,Xie MJ,et al.Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155,and its restoration inhibits pancreatic tumor development[J].Prec Nail Acad Sci U S A,2007,104(41):16170-5.
    [15]
    Zhou LS, Li DP, Wang B, et al.The relative parameters of liver metastasis of colorectal carcinoma after surgery[J]. Zhongguo Ai Zheng Za Zhi,2006,16(5):394-5.[周立生,李大鹏, 王斌,等.结直肠癌术后肝转移相关因素分析[J].中国癌症杂 志,2006,16(5):394-5.]
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    Corresponding author: CAO Hongliang, sunflower71978@126.com

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