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YU Yin-yan, ZENG Bin, CHAI Li-min, YANG Shu-guang, LI Chang-lin, ZHANG Yuan, YANG Rong-cun. Effect of SerpinH1 on Proliferation and Growth of Murine Tumor[J]. Cancer Research on Prevention and Treatment, 2009, 36(09): 741-744. DOI: 10.3971/j.issn.1000-8578.2009.09.006
Citation: YU Yin-yan, ZENG Bin, CHAI Li-min, YANG Shu-guang, LI Chang-lin, ZHANG Yuan, YANG Rong-cun. Effect of SerpinH1 on Proliferation and Growth of Murine Tumor[J]. Cancer Research on Prevention and Treatment, 2009, 36(09): 741-744. DOI: 10.3971/j.issn.1000-8578.2009.09.006
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Effect of SerpinH1 on Proliferation and Growth of Murine Tumor

  • Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China

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  • Received Date: June 30, 2008
  • Revised Date: September 27, 2008
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  • Objective To investigate the effects of SerpinH1 on the proliferation of murine tumor. Methods We first cloned SerpinH1 and set up SerpinH1 targeted siRNA structure, and then investigated the effects of SerpinH1 on the tumor cell proliferation and growth. The inhibition of cell proliferation and growth was demonstrated by both WST-1 cell proliferation assay and 5′-bromo-2′-deoxy-uridine incorporation assay with flow cytometry (FACS). Results The expression of SerpinH1 could inhibit the proliferation of the monocyte tumor RAW264.7 cells and melanoma B16 cells. Meanwhile silencing SerpinH1 could promote the proliferation of both RAW264.7 and B16 cells. Conclusion The results indicated that SerpinH1 could inhibit the proliferation and growth of both RAW264.7 and B16 tumor cells.
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