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1996  Vol. 23  No. 6

Changes of micronuclei frequence of peripheral blood lymphocytes on MNNG-induced experimental gastric carcinoma and precancerous lesion by garlic and garlic-green tea mixture
Abstract:
The effect of garlic and garlic-green tea mixture for micronculei frequence (MNF) of peripheral blood lymphcytes(PBL)on gastric carcinoma(GC) and pre cancerous lesion(PL) in Wistar rats induced by N-methyl-N-nitro一N'一nitrosoguani-dine (MNNG) is studied.The results show,that MNF of MNNG group (MG) by the 10th month and 16th month is similar,of MG,GC and PL is Niger remarkably than control group(CG) (P<0.001),respectively,of PL is lower than GC (P<0.001),of prevention group (PG),treatment groupI(TGI) and II(TGII) decrease,the differance with MG is significant (P<0.01),PG by the 16th month is lower than 10th month
The relation of erythroblast in peripheral blood of acute leukemia to rosponse for treatment and prognosis
Abstract:
Erythroblast in peripheral blood of 181 patients with acute Leukemia were observed,The results showed that 32.}0% patients in ANLL and 28.800 patients in ALL had erythroblast in peripheral blood.There were no relation between erythroblast in peripheral blood in acute leukemia and anemia.In ANLL,the patients which hadn't erythroblast in peripheral blood had better response for treatment and higher complete remission rate,it is more obvious in M,and MS subtypes.The during of survival was also longer.It indicated that the observation of erythroblast in peripheral blood might be taken as a supplem entary indication in judgement the effect of treatment and prognosis in ANLL.
Expression of EGFR. neu and PCNA in 70 Patients with ovarian Surous Cystadenocarcinoma and Their Clinical Significance
Abstract:
The expression of EGFR、neu and PCNA in 70 Patients with ovarian surous cystadenocarcinoma was observed with immunohistochemical technique in this study.The relationship between the expression and clinical feature including various pathological grades,clinical stages and prognosis was studied.The results showed that in these 70 patients EGFR was positive in 41(58.5%),neu was posttive in 32(45.7%),PCNA was positive in 33(47%).EGFR、 neu and PCNA expression was significantly correlated to the pathological grade and clinical prognosis.
Effect of Immunosuppressive Factor Produced By Cervical Cancer Cell On IL-2 Responsiveness
Abstract:
Cervical cancer cell lines produced a tumor-derived immunosuppressive factor (TDSF ),which inhibited the production of IL-2 after 6h incubation with PBMC,the response of PBMC treated with PHA-p to exogeneous IL-2 was significantly decreased in the presence of TDSF,suggesting that could inhibit the res poinsiveness of IL-2.The effect of PBMC after being stimulated with PHA-p was significantly suppressed by TDSF in does-dependent manner.These finding suggest that the inhibitory action of TDSF on T cell activation and proliferation mediated with IL-2.The synthesis or secretion of TDSF in cervical were partially inhibited by anticancer drubs.
The in Sterigmatocystin Carcinogenesis Cultured Human Gasttric Mucosae
Abstract:
Zanhuang county of Hebei Province in China is a high risk area of stomach cancer.Our previous studies showed that the carcinog enesis of stomach in this area was closely associated with sterigmatocystin(ST).In the present study,cultured human fetal gastric mucosae were treated with ST and 18 days latey,the gastric mucosae were analyzed with flow cytometer and subcutaneously inoculated into the r-ray irradiated SD newborn rats respectively.The results indicated that the cell numbers in S and G2M phases in cell cycle and Proliferation Index from the ST-treated mucosae increased dramatically compared with that from mucosae in contral group,and the mucosae in the ST-treated explants inoculated into the rats appeared morphologically severe atypical hyperplasia changes,in contrast,the inoculated explants in the control group disappeared completely.These results suggest showed that ST may be a carcinogen for human gastric mucosae.
Study on the Change Tendency of SOD Activity in Wistar Rats and Kunming Mice after dietary Aflatoxin B1 and Ge-132
Abstract:
In order to investigate AFB,metabolic pathway in vivo and relationship between Ge-132 and the free radical,the SOD activity in Wistar rats and Kunming maces which had been intaken AFB1 and Ge-132 before and after were determined.The results showed that the changing tendency of SOD in rats and maces was similar.AFB1could signficantly reduce the SOD activity in red blood cell,serum and liver tissue.The SOD activity both in rats and mites was stimulated after intaken Ge-132.Inhibitory of the SOD activity by single injection AFB1 graduated away at last.Wistar rats were more sensitive to AFB1 than Kunming mites.
The clinicopathological significance of neuroendocrine cells in gastric carcinoma
Abstract:
One hundred and twenty cases of gastric carcinoma were examined with immunohistochemical SP method for chromogranin A (CgA),gastrin (GAS),somatostain (SS) and serotonin(5-HT)follows:Among four antibodies,CgA was most specific,31.7%gastric carcinoma had CgA-positive cells;the positive rate of CgA in the well differentiated carcinomas was higher than that of the poorly differentiated ones and undifferentiated carcinomas (P<0.05),CgA-positive undifferentiated carcinomas had more NE cells(++);but among different histological type,the positive rate of HT and SS in undifferentiated carcinomas was lower (P>0.05).CgA and HT positive cases had higher lymph node metastasis rate than the negative ones (P<0.05).The cases with CgA-positive cells(++)exhibited shorter survival time than those with few CgA-positive cells(+)and without CgA-positive cells
Study on apoptosis of hepatocellular carcinoma cells after intrahepatic arterial angiotensin Ⅱ infusion induced hypertension and chemoembolization (IHCE )
Abstract:
Apoptosis of hepatocellular carcinoma cells in 11 cases with two stage resection after IHCE was studied,compared with 9 cases with two stage resection after TCE and 10 cases with first stage resection.Apoptotic tumor cells showed typical morphological appearence in H·E Stainnig slides.Quantification of apoptosis using flow cytometry,the apoptotic cells accounted for 42.8±27.4%in IHCE group,25.3±10.8 0 o in TCE group,and 4.9±3.4%in first stage resection group.IHCE cound induce more a oontnsis of tumor cells than TCE did.
The Application of Fetal Liver Cell Transfusion in Patients with Moderate and Advanced Solid Tumor
Abstract:
Thirty-six cases of patients with moderate and advanced solid tumor treated with Fetal Lital Cell (FCL) Transfusion.The result showed that the FLC transfulion can retrieve myelosuppression caused by chemotherapic Burgs obviously and promote the fuctions of hematopoiesis and immunity.The peripheral blood picture and general symptoms of the patients can be improved rapidly.FLC transfusion can provide a fevourable condition for chemotherapy or radiotherapy and prolonge the sarvival times.
An Observation on Therapeutic effectiveness of Combined Chemotherapy in 80 Advanced Cases of Carcinoma of Stomach
Abstract:
80 cases of advanced gastric cancer treated in accordance with the four chemotherapeutic plans,FAM、FOM、WIF and EAP,were evaluated,and no statistical significance was suggested,with the effective rate respectively being 45% and 55%,45%,and 55%.The median survival period for each group was respectively 5.8,5.6,5.2 and 6.7 months.The major side effects were nausea cytopenia,thrombopenia and alopecia,while none of the cases was vomiting,panforced to quit the treatment due to the case effects.
Askin Tumor
Abstract:
Askin tumor is belonged to the malignant neuroendocrine tumor of soft tissure which has been established in the recent year.It is rare in the clinical practice.It has a main predilection on the chest wall with an obvious tendency of local recurrence and metastasis.It resemble the neuroendocrine carcinoma from other sites of the body in morphology,immunohistochemistry and ultrastracture.It is difficult to diagnose this tumor.Based upon one case as verified by operation、light and electronmicroscope,the diagnosic standard、the differential diagnosis、the therapeutic method and pathagenical feature are discussed and the literatures are reviewed.
Treatment of Cancerous pain with the Compound Tramadol solution
Abstract:
Twenty patients with cancerous pain were treated with the compound Tramadol solution and the effects of analgesia were studied.The results showed that the analgesic effeets were obvious when the solution was injected into any fo the 3 different positions.The analgesic time was 13.16±9.26 hours.We conclude the solution is a safe,potent and long-acting analgesic and is more effecaive than simple tramadol.It is possible that the solution supersede morphine to treat cancerous pain.
Cervical Metastatic Adenocarcinoma from Gastric Reports 11 Cases
Abstract:
Gastric cancer metastasis to cervix is very rary.This paper reports 11 cases.By systemic analysis.the result shows that:(1)The most patients were younger than 40;(2) This disease always occurs in three years after the treatment of original tumor;(3) The pathological feutures were predominantly entirely undifferentiated or poorly differentiated adenocarcinoma;(4) Reginoal lymph mode had been involved at the time of gastrectomg in all patients.The author thinks the metasta- sis pattern of this diseases may be by lymphatic drainage and we suggests that pelvic examenation should be routine in the follow up after surgery of gastric cancer.
Ovarian mucinous tumor with sarcoma-like mural nodules in gestational period
Abstract:
One case otpregnant woman of muinous ovarian tumor with sarcoma-like nodulesnal in its wall is reported.The age of patient is 29 years.She had a large mass with pregnancy for 8 months.The specimens contained 9 discrete nodules in its wall,nodules were soft,dark brown and hemorrhagec.On microscopical examination the epithelial component of tumor laged from benign,borderlin malignancy to well-differeutiatgd carcinona.The spindle-cells,pleomorphism cell,gainte cells,multinucleale giant cell and histocytic cells were encounted in the nodules.According to these case research it suggests that mural nodules of the typs discribed are not sarcomotous but could represent a reafive process.
Combination Treatment Analyses of Middle and Advanced Stage Vulvar Carcinoma of 44 Cases
Abstract:
From 1976 to 1992,44 patients with middle and advanced stage vulvar carcinoma were treated by radical vulvectomy combined with radiation therapy and chemotherapy in our hospital.The age of patients over 60 years was 43 percent.The most common presentation was a vulvar mass which has begun to enlarge,or produce pruritus or a serous discharge.According to the FIGO stage.16 cases was with stage Ⅱ;25 cases stage Ⅲ and 3 cases stage Ⅳ 43% cases was followed up.1.3,5-year survival rates for this study were 93%;64%;43%,respectively.According to this report,it has demonstrated that radical vulvectomy combined with radiation therapy and chemotherapy is superior to alone treatment.
A Comparative Study of Pirarubicin(THP) and Adriamycin(ADM)on Side Effects
Abstract:
71 cases(183 treatment courses)of various malignancies were treated with THP containing combination chemotherapy,while 106 cases(269 treatment courses) were treated with ADM combinations as contrl.A comparative study was carried out between two groups on side effects caused from THP or ADM.The resuits showed that the most remarkable difference was that in the THP group alopecia,side effects on heart,nausea and vomting were far less than in the ADM control group.It is not significance for the differences between two groups on other side effects including marrow damage,oral cavity ulcer,body temperature going up,and the function damage on liver or kidney.