Effect of Immunosuppressive Factor Produced By Cervical Cancer Cell On IL-2 Responsiveness

Cervical cancer cell lines produced a tumor-derived immunosuppressive factor (TDSF ),which inhibited the production of IL-2 after 6h incubation with PBMC,the response of PBMC treated with PHA-p to exogeneous IL-2 was significantly decreased in the presence of TDSF,suggesting that could inhibit the res poinsiveness of IL-2.The effect of PBMC after being stimulated with PHA-p was significantly suppressed by TDSF in does-dependent manner.These finding suggest that the inhibitory action of TDSF on T cell activation and proliferation mediated with IL-2.The synthesis or secretion of TDSF in cervical were partially inhibited by anticancer drubs.