乳腺导管不典型增生与癌变的关系
RELATIONSHIP BETWEEN DUCTAL EPITHELIAL ATYPICAL HYPERPLASIA AND MALIGNANT TRANSFORMATION IN THE BREAST
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摘要: 本文总结经手术活检确诊的女性乳腺囊性增生病325例。将乳腺导管或腺泡上皮增生程度分为三级。首次活检Ⅰ级77.29%,Ⅱ级16.3%,Ⅲ级4.92%,早期癌变5例。经2～7年随访,再次活检28例、上皮增生程度加重4例;另有5例原Ⅱ级以上增生者发生癌变。上皮不典型增生程度有随年龄增长而加重趋势。癌变病例主要发生在40岁以上年龄组。癌变率为3.1%。本文探讨了可能导致不典型增生上皮细胞癌变的部分机制和临床治疗措施。Abstract: A group of 325 female patients with fibrocystic breast disease comtirmed by biopsy were analyzed The breast lesions were classified into three grades accord ing to the epithelial hyperplasia degree of duct or acirus, of these, Grade Ⅰ was 251 cases (77.20%), Grade Ⅱ 53 cases (16.3%), Grade Ⅲ 16 cases (4.90%) and the rest 5 cases had early malignant transformation. After 2 to 7 years followed-up, 28 cases had performed another biopsy, 4 of them occured malignant transformation. we concluded: the extention of atypical hyperplasia may aggravated concomitantly with the age increasing, the frequent age interval of malignant transformation was 40.
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