高级搜索

淋巴结反应性滤泡增生与滤泡型淋巴瘤的鉴别要点

纪小龙, 罗良明

纪小龙, 罗良明. 淋巴结反应性滤泡增生与滤泡型淋巴瘤的鉴别要点[J]. 肿瘤防治研究, 1996, 23(3): 140-142.
引用本文: 纪小龙, 罗良明. 淋巴结反应性滤泡增生与滤泡型淋巴瘤的鉴别要点[J]. 肿瘤防治研究, 1996, 23(3): 140-142.
Ji Xiaolong, . Differential diagnosis between reactive follicular hyperplasia and follicular lymphoma[J]. Cancer Research on Prevention and Treatment, 1996, 23(3): 140-142.
Citation: Ji Xiaolong, . Differential diagnosis between reactive follicular hyperplasia and follicular lymphoma[J]. Cancer Research on Prevention and Treatment, 1996, 23(3): 140-142.

淋巴结反应性滤泡增生与滤泡型淋巴瘤的鉴别要点

Differential diagnosis between reactive follicular hyperplasia and follicular lymphoma

  • 摘要: 淋巴结病理诊断中难题之一是反应性滤泡增生与滤泡型淋巴瘤的鉴别。本文归纳了两者鉴别的要点:(1)临床上以年龄及基础疾病有鉴别意义;(2)组织结构上难以有可靠的鉴别点;(3)细胞形态上以滤泡内外细胞一致有鉴别意义;(4)免疫组化上单克隆性见于90%的淋巴瘤;(5)基因表达异常上85-90%淋巴瘤有染色体移位。bcl-2免疫组化有鉴别意义。

     

    Abstract: Distinction between follicular lymphoma and reactive follicular hyperplasia is a common problem in routine pathological diagnosis. The main fields are as follows:(1) clinical course; (2) architectural features of lymph node; (3) cytological polymorphism or monomorphism; (4) immunohistochemistry of monoclonal lymphocytes; (5) bcl-2 gene product.

     

  • 1. Dorfman RF, Warnke R. Lymphadenopathy simulating the malignant lymphomas. Hum Pathol, 1975,5:519.
    2. Weisenburger DD, Chan WC. Lymphomas.of follicles. Mantle cell and follicular center cell lymphomas. Am J Clin Pathol, 1993, 99 :409.
    3. Nathwani BN. Diagnostic significance morphologic patterns in lymph node proliferations, in Knowles DM (ed):Neoplastic Hematopathology. Baltimore, MD Williams and Wilkins, 1992:410-417.
    4. Picker LJ, Weiss LM, Medeiros LJ,et al. lmmunophenotypic criteria for the diagnosis of nonHodgkin's lymphoma. Am J Pathol, 1987,128:181.
    5. Jaffe ES. The role of immunophenotypic markers in the classification of non-Hodgkin's lymphomas. Semin Uncol, 1990, 17:11.
    6. Chilosi M. Mombello A, Nenestrina F, et al. Immunohistochemical differentiation of follicular lymphoma from florid reaction follicular hyperplasia with monoclonal antibodies reactive on paraffin sections. Cancer,1990, 65:1562.
    7. Chen YT, Godwin TA, Mouradian JA. Immunohistochemistry and gene rearrangement studies in the diagnosis of malignant lymphomas. A comparison of 152 cases. Hum Pathol, 1991, 22:1249.
    8. Weiss LM, Warnke RA, Sklar J, et al. Molecular analysis of the t (14:18) chromosomal translocation in malignant lymphomas. N Engl J Med, 1987, 317:1185.
    9. Pezzella F, Tse AGD, Corded JL, et al. Expression of the bcl-2 oncogene protein is not specific for the 14,18 chromosomal translocation. Am J Pathol, 1990, 137:225
    10 Sander CA, Yano T, Clark H, et al. P53 mutation is assoSiated with progression in follicular lymphomas.Blood,1993, 82:1994.
计量
  • 文章访问数:  3490
  • HTML全文浏览量:  51
  • PDF下载量:  481
  • 被引次数: 0
出版历程
  • 刊出日期:  1996-06-04

目录

    /

    返回文章
    返回
    x 关闭 永久关闭