淋巴结反应性滤泡增生与滤泡型淋巴瘤的鉴别要点

Differential diagnosis between reactive follicular hyperplasia and follicular lymphoma

摘要: 淋巴结病理诊断中难题之一是反应性滤泡增生与滤泡型淋巴瘤的鉴别。本文归纳了两者鉴别的要点：（1）临床上以年龄及基础疾病有鉴别意义；（2）组织结构上难以有可靠的鉴别点；（3）细胞形态上以滤泡内外细胞一致有鉴别意义；（4）免疫组化上单克隆性见于90%的淋巴瘤；（5）基因表达异常上85-90%淋巴瘤有染色体移位。bcl-2免疫组化有鉴别意义。

Abstract: Distinction between follicular lymphoma and reactive follicular hyperplasia is a common problem in routine pathological diagnosis. The main fields are as follows:(1) clinical course; (2) architectural features of lymph node; (3) cytological polymorphism or monomorphism; (4) immunohistochemistry of monoclonal lymphocytes; (5) bcl-2 gene product.