Abstract: The overexpression of transcription factor HOXB7 in tumor tissue is often closely related to tumor staging and prognosis. Studies have shown that HOXB7 plays important roles in not only cell proliferation and apoptosis but also in tumor metastasis process. Multiple signal transduction pathways could regulate the expression and activation of HOXB7 while HOXB7 could also affect multiple important factors in the pathway. It has become a potential target for tumor therapy.