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人类白细胞抗原-E基因多态性与乳腺癌遗传易感性的关系

周艳, 吴振村, 程健君, 贾天军

周艳, 吴振村, 程健君, 贾天军. 人类白细胞抗原-E基因多态性与乳腺癌遗传易感性的关系[J]. 肿瘤防治研究, 2015, 42(02): 190-193. DOI: 10.3971/j.issn.1000-8578.2015.02.020
引用本文: 周艳, 吴振村, 程健君, 贾天军. 人类白细胞抗原-E基因多态性与乳腺癌遗传易感性的关系[J]. 肿瘤防治研究, 2015, 42(02): 190-193. DOI: 10.3971/j.issn.1000-8578.2015.02.020
ZHOU Yan, WU Zhencun, CHENG Jianjun, JIA Tianjun. Association of HLA-E Gene Polymorphisms with Genetic Susceptibility to Breast Carcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 190-193. DOI: 10.3971/j.issn.1000-8578.2015.02.020
Citation: ZHOU Yan, WU Zhencun, CHENG Jianjun, JIA Tianjun. Association of HLA-E Gene Polymorphisms with Genetic Susceptibility to Breast Carcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 190-193. DOI: 10.3971/j.issn.1000-8578.2015.02.020

人类白细胞抗原-E基因多态性与乳腺癌遗传易感性的关系

基金项目: 河北省教育厅重点科研项目(Z2011208);河北北方学院青年基金资助项目
详细信息
    作者简介:

    周艳(1980-),女,硕士,讲师,主要从事肿瘤方面的研究

    通信作者:

    贾天军,E-mail: jiatianjun@yahoo.com

  • 中图分类号: R737.9

Association of HLA-E Gene Polymorphisms with Genetic Susceptibility to Breast Carcinoma

  • 摘要: 目的 探讨人类白细胞抗原-E(HLA-E) 基因多态性与中国张家口地区汉族女性乳腺癌遗传易感性的关系。方法 采用聚合酶链反应-序列特异性引物(PCR-SSP)法对中国张家口地区200例乳腺癌患者和114例健康对照人群HLA-E等位基因进行检测。结果 乳腺癌患者和健康对照组均检出两种等位基因:HLA-E*0101和HLA-E*0103;共检出三种基因型:HLA-E*0101/ HLA-E*0101、HLA-E*0101/HLA-E*0103和HLA-E*0103/ HLA-E*0103。其中HLA-E*0103等位基因和HLA-E*0103/HLA-E*0103基因型在乳腺癌患者组的分布频率明显高于健康对照组,差异有统计学意义(P <0.01)。且携带HLA-E*0103/ HLA-E*0103基因型的个体乳腺癌发病风险明显增加(OR=2.05,P=0.004)。结论 HLA-E基因多态性与中国张家口地区汉族女性乳腺癌遗传易感性相关,并且HLA-E*0103/ HLA-E*0103等位基因可能是易感基因。

     

    Abstract: Objective To investigate the association between HLA-E gene polymorphisms and genetic susceptibility of female breast carcinoma in Han Nationality in Zhangjiakou, China. Methods HLA-E typing was performed for 200 breast cancer patients and 114 healthy controls from Zhangjiakou area by polymerase chain reaction-sequence-specific priming (PCR-SSP). Results Two alleles of HLA-E could be detected, HLA-E*0101 and HLA-E*0103; simultaneously three genotypes were detected, namely HLA-E*0101/0101, HLA-E*0101/0103 and HLA-E*0103/0103. The frequencies of HLA-E*0103 allele and HLA-E*0103/HLA-E*0103 genotype were significant different between healthy controls and breast cancer patients(P<0.01). The risk of breast cancer was significantly increased in HLA-E*0103/ HLA-E*0103 genotype(OR=2.05, P=0.004). Conclusion HLA-E gene polymorphisms are associated with the development of female breast cancer of the Han in Zhangjiakou, China; moreover, HLA-E*0103/ HLA-E*0103 genotype is probably the susceptible genotype.

     

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出版历程
  • 收稿日期:  2014-02-19
  • 修回日期:  2014-09-16
  • 刊出日期:  2015-02-24

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