Abstract: A case of primary APUDoma in an unusual location, the liver, is reported. The neoplasm was composed of small, uniform cells that had distinct borders and grew in strands, ribbons and nests, it s appearance resembled that of a carci- void. Electron microscopy and special staining of:he neoplastic cells confirmed the neuroendocrine nature of the tumor, and .the cells showed immunoreactivity for gastrin and pancreatic polypeptide by the PAP.The recent literature is reviewed and the possible histogenesis of hepatic PUDonia is discussed.