应用免疫组化方法观察胰腺癌PS—4抗原在胃癌及癌前组织中的表达

EXPRESSION OF PANCREATIC CANCER RELATED ANTIGEN PS 4 IN GASTRIC CANCER AND ITS PRECANCEROUS LESION

摘要: 应用免疫组化方法观察了胰腺癌PS-4相关抗原在117例手术切除胃癌标本及343例胃粘膜活检肠化标本中的表达。117例胃癌染色阳性93例,阳性率为79.5%。正常胃粘膜染色均为阴性。应用粘液组化技术将肠化分为Ⅰ、Ⅱ和Ⅲ型,发现Ⅲ型肠化PS-4抗原染色阳性率显著高于Ⅰ、Ⅱ型肠化(P＜0.01),提示Ⅲ型肠化与胃癌关系密切。结果表明,检测胃粘膜组织中PS-4抗原对胃癌的诊断和胃癌高危患者的筛选可能有重要意义。

Abstract: The expression of pancreatic cancer-related antigen PS-4 was investigated in 117 gastrectomy specimens of gastric caner and 343 biopsy specimens of intestinal metaplasia by immunohistochemical technique. Among the 117 cases of gastric cancer, 93 (79.5%) showed the positive reaction for PS-4 antigen, while no positive reaction was found in normal gastric mucosa. Intestinal metaplasia was classified into types Ⅰ, Ⅱ and Ⅲ by histochemical mucin stainings. In different types intestinal metaplasia, type Ⅲ exhibited a significantly higher positive rate for PS-4 antigen than types Ⅰ and Ⅱ (P0.01), suggesting that typa Ⅲ intestinal metaplasia is cioseiy related to the histogenesis of gastric cancer. Our results indicate that PS-4 antigen may be valuable tumor marker in detecting gastric cancer and defining the highrisk group of gastric cancer.