胃癌、大肠癌及癌前病变中MGcl单克隆抗体的表达及其意义
Expression And Significance of MGcl Monoclonal Antibody in Gastrointestinal Carcinoma and Precancerous Intestinal Lesions
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摘要: 应用肠型胃癌单克隆抗体MGcl,PAP免疫组化染色,对大肠癌、胃癌、大肠腺瘤等进行标记,发现胃癌MGcl阳性率为85.7%;大肠癌、大肠腺瘤和炎性息肉阳性率分别为90.7%、45.8%和13.0%,三组有显著差异(P<0.05).绒毛状和绒毛管状腺癌明显阳性者高于管状腺瘤(P<0.05).结果表明,MGcl免疫组化标记对于大肠癌和癌前病变的诊断和估计预后有意义.Abstract: Immunohistochemical staining of MGcl monoclonal antibody was carried out in 63 cases of gastric carcinorma, 108 cases of large bowel carcinoma, 48 cases of Large bowel adenoma and 23 cases of inflammatory polar.The rate of MGcl staining was 85. 7%, 90. 7%, 45. 8% and 13. 0% respectively. Among the large bowel adenoma I the obviously positive staining rates of MGcl staining in villous and villo-tubular adenolma were higher than that in tubular adenoma. It was suggested that the immunohistochmical staihing of MGcl miyght be helpful in the diagnosis of gastrointestinal carcinoma and in the surveillance of precancerous diseases.
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Key words:
- La bowel carcinoma /
- gastric carcinoma /
- Large bowel adenoma /
- monoclonal antibody
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1. 胡家露,等.胃粘膜不典型增生的MGcl抗原表达及其与胃癌的关系.中华医学杂志,1988, 68(7): 363 2. 樊代明,等.抗肠型胃癌单克隆抗体的制备及意义.第四军医大学学报,1988, 9(4): 230 3. 孙智材,等.胃粘膜上皮不典型增生的MGcl抗原表达与病理的关系.中华消化杂志,1990, 10(5): 304 4. Muto T, et al. The evolution of cancer of the colon and rectum. Cancer, 1975. 36: 2251
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