免疫耐受动物人瘤异种移植模型建立的研究──Ⅱ、叙利亚仓鼠人胃癌导种移植模型的免疫功能测定
STUDY ON ESTABLISHING A MODEL OF HUMAN TUMOR XENOGRAFT WITH IMMUNOTOLERANCE ANIMAL
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摘要: 给新生叙利亚仓鼠腹腔和皮下接种人胃癌BGC—823细胞株,建立了人胃癌异种移植模型.通过EST、QHS和腹腔巨噬细胞吞噬试验证实:荷瘤仓鼠的免疫功能与同龄正常仓鼠相近,统计学没有显著性差异.
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关键词:
- 耳肿试验（EST） /
- 定量溶血分光光度测定（QHS） /
- 腹腔巨噬细胞吞噬功能测定
Abstract: A xenograft model of human gastric carcinoma has been established by inoculating human gastric carcinoma BGC-823 cells to abdominal cavity and Subcutaneous tissues of new born Syrian Hamster. Experiments of EST,QHS and macrophage phagocytic function test shows that the immune function of Carrying-tumor Hamsters was similar to that of the normal Hamsters of same age,and no obvious differences were shown on statistics. -
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1. 刘文泰,等.叙利亚仓鼠人胃癌异种移植模型的建立.肿瘤防治研究,1993,20(4):225 2. Man-sun S Y,et a1. Immune suppression with supraoptimal doses of antigen in contact sensitivity,J Immunology,1977,119(1):240
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