肿瘤病人化疗、免疗及免疫化疗前后NK－IL－2－IFN－r系统变化
EFFECTS OF CHEMOTHERAPY, IMMUNOTHERAPY AND IMMUNOCHEMOTHERAPY ON NK-IL-2-IFN-R IN CANCER PATIENTS
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摘要: 本文观察了46例中晚期肿瘤病人化疗、免疗(抗瘤iRNA及S-TF)及免疫化疗前后NK-IL-2-IFN-r系统及WBC等变化.结果发现:(1)肿瘤病人NK、IL-2及IFN-r活性均显著低于正常人;(2)化疗后除WBC明显降低外,其它指标化疗前后均无明显变化;(3)免疫及免疫化疗后各免疫指标均较治疗前显著增加;(4)免化组各免疫指标及WBC明显高于化疗组,其中IL-2及IFN-r活性还明显高于免疫组,但免疫组仅IL-2活性及WBC明显高于化疗组.本研究结果表明,抗瘤iRNA及S-TF不仅可恢复肿瘤宿主的免疫力,而且与化疗联用,还可能降低化疗的毒副反应,协调肿瘤病人NK-IL-2-IFN-r系统的抗癌功能.Abstract: Abstract Chemotherspy, immunotherapy and immunochemotherapy were tested for thire effects on NK-IL-2-IFN-r in 46 patients with advanced cancer. The results showed that (1) the NK, IL-2 andIFN-r activities in the cancer patients were significantly lower than those in controls;(2) both be- fore and after chemotherapy there were no apparently changes in the NK, IL-2 and IFN-r activityexcept for WBC; (3) the immune indexes were apparently increased after immunotherapy and immunochemotherapy as compared to those before, and (4) the IL-2 and IFN-r activity in immunochemotherapy group were significantly higher than chemotherapy and immunotherapy grouprespectively, but the NK activity in immunochemotherapy group was significantly than that only inchemotherapy group and the IL-2 activity and WBC in immunotherapy group were apparentlyhigher than those in chemotherapy group. It is concluded that the immune function in the host canbe restored by adiministrating iRNA and S-TF, and either the side effects of chemotherapy can bereduced or an synergistical immunoregulation of NK-IL-2-IFN-r aganist cancer can be enhanced inthe patients by combining chemotherapy with iRNA and S-TF.
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