胃幽门螺杆菌感染与胃癌发生关系的病理学观察
Pathologic Observation of Ralation Between the Carcinoma of Stomach and the Infection of Helicobacter Pylori
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摘要: 本文采用先进的PCR技术对56例胃癌、60例慢性胃炎及12例正常胃粘膜组织作了幽门螺杆菌的检测。结果，胃炎中幽门螺杆菌（HelicobacterPylori,HP）检出率93.33%,胃癌组织中检出率41.07%,正常胃粘膜中仅为16.67%.提示，胃炎的发生与HP感染明显相关，胃癌的发生与HP感染有一定的关系。从胃癌的发生部位来看，贲门癌HP感染率极低（9.52%）,而胃窦部及小弯区的癌组织中HP感染率高（68%,37.5%）,与HP易感部位在窦部及小弯处是一致的。可能是旺感染造成胃粘膜损伤、粘膜细胞活跃增生，增加了对致癌物质的敏感性。而贲门癌的发生与HP感染无关从病理分型的角度看，分化型（腺样型）的癌组织中感染率较高（55.88%）,低分化型（弥漫型）中较低（20%）,2例粘液癌中均未测到HP.本研究中分化型胃癌多位于胃窦区及小弯区，也进一步支持这一观点，另外，HP感染率在较低社会阶层人群中较高，与本文胃炎及胃癌的病员来源情况一致。Abstract: By techanique of Polymerase Chain Reaction, we analysed 56 cases of carcinoma of stomach, 60 cases of gastritis and 12 cases of normal gastric tissues. The results showed that: the infection rates of Hp were 41. 07%, 93. 3% and 16. 67%,respectively. The infection rates of carcinomas at the upper of stomach was much lower (9. 52 %)than at the middle and parts (68%, 37. 5%). The infection rates of differentiated carcinomas was 55. 8%, but poorly differentiated carcinomas was 20%.
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Key words:
- Helicobacter Pylori /
- carcinoma of stomach /
- gastritis
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1. 赵立群.中国农村自然人群中胃幽门螺杆菌感染率与胃炎的关系.中华消化杂志,1992, 12(1) j 33. 2. 宋伯根,李义清,赵桂芬,等.胃枯膜损伤程度与胃癌发生关系.庙症,1993, 12(5):372. 3. 张建中.幽门螺杆菌感染流行病学研究进展.中华流行病学杂志,1993, 14(5):310. 4. 小松正子.痛の临床,1992, 38(3):358.
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