女性肺癌患者性激素受体改变的研究

李军; 刘志民; 招镜尧; 罗文侗

女性肺癌患者性激素受体改变的研究

第二军医大学长征医院, 上海 200003

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出版历程
- 刊出日期: 1998-04-04

Changes of the concentration of sexual hormones and the content of sexual hormone receptors in women with lung cancer

Li Jun,

Respiratory Division, Changzheng Hospital, Second Military Medical College, Shanghai 200003

摘要

摘要: 本文用放射配体结合分析法测定22例女性肺癌患者外周血白细胞雌激素受体（ER）和雄激素受体（AR）的变化，结果示女性肺癌患者血浆雌二醇（E₂）水平育龄期患者明显高于育龄期对照组，绝经期患者与绝经期对照组比较差别无显著性意义。ER均明显增高，AR明显降低，ER／AR比值较年龄匹配的正常对照组明显升高。所有患者血浆睾酮（T）水平均明显低于正常对照组，E₂／T比值明显高于对照组，提示性激素及性激素受体的改变在女性肺癌发生发展中起一定作用。
- 雌二醇 /
- 睾酮 /
- 受体 /
- 雌激素 /
- 雄激素
Abstract: The binding capacity of estrogen receptor (ER) and rogen receptor(AR) in peripheral leucocytes in women with lung cancer was determined by the method of radioligand binding assay and plasma estradiol (E₂) and testosterone (T) levels were simultaneously measured by radioimmune assay in 22 women lung cancer. The results were compared with those of 25 age-matched healthy Women. It was found that the level of plasma estradiol (E₂) was significantly increased in 5 patients with normal menstrual cycle,but not in 17 patients with menopsuse.The level of testosterone was significantly decreased in all the patients. The ratio of E₂ to T was also significantly increased. The result still showed that the content of AR in leucocytes was obviosly lowered and the content of ER and the ratio of ER to AR were obviously elevated. It suggested that the disturbance of E₂ and T and their receptors may play an important role in the pathogenesis of lung cancer in women.
- estradiol /
- testosterone /
- estrogen /
- receptor /
- androgen

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参考文献(5)

1. 陈国安, 杨德昌, 何积银. 肺癌患者血中性激素. 皮质醇及癌胚抗原水平的研究. 陕西医学杂志, 1992, 21(12):710

2. 杨梅怀, 张岩峰, 潘堤华. 女性肺癌患者雌激素受体检测的研究. 中华结核和呼吸杂志, 1992, 15(3):138

3. 赵瑛, 刘志民, 邵福源, 等. 人外周血白细胞雄激素受体的鉴定及意义. 中华核医学杂志. 1995, 15(1):51

4. 顾百诚, 景沛. 人白细胞雌二醇受体的测定. 中华内分泌代谢杂志, 1986, 2(2):102

5. Canver CC, Memoli VA, Vanderveer PL, et al. Sex hormone receptors in non-small-cell lung cancer in human beings. J Thorac Cardiovasc Surg, 1994, 108:153