Application Perspectives of Targeted Ultrasound Contrast Agents in Diagnosis and Therapy of Cancer
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摘要:
随着癌症发病率和死亡率的持续增加，靶向超声造影剂介导的超声诊断技术和治疗技术对癌症的二级预防和三级预防具有积极影响。尽管靶向超声造影剂目前仍然处于临床前实验阶段，但是已经初步展现出其突出的应用价值。它能够在癌症鉴别、疗效监测以及作为基因和药物载体介导癌症靶向治疗等方面发挥重要作用，最终得以实现癌症诊断治疗一体化。近期，国外研究还证实靶向超声造影剂具有抗肿瘤血管作用从而增强放疗效果。靶向超声造影剂介导的分子成像、精准化疗、靶向基因治疗、放疗增敏是实现“精准医疗”的重要支持技术，总结近年来靶向超声造影剂在肿瘤疾病中的研究进展和应用潜力能够进一步推进其向临床应用的转化。
Abstract:Cancer has become the important social problems in China with its increasing incidence and mortality. Targeted ultrasound contrast agents-mediated ultrasound molecular diagnostic techniques and targeted therapeutic techniques may contribute to secondary prevention and tertiary prevention of cancer. Targeted ultrasound contrast agents have shown a prominent application value for its good advantage in cancer identification, efficacy monitoring, and serving as the gene and drug carriers to mediate cancer targeted therapy, and ultimately achieving the integration of cancer diagnosis and therapy though they are currently still in preclinical stage. Recently, foreign studies have also confirmed that targeted ultrasound contrast agents have anti-vascular effects and thus enhance the radiotherapy effect. Targeted ultrasound contrast agents-mediated ultrasound molecular imaging, precise chemotherapy, targeted gene therapy, radiotherapy sensitization are important support technologies of "precision medicine". It will help to further accelerate ultrasound contrast agents translating into clinical applications by summarizing its recent progress and potential clinical application.
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Key words:
- Targeted ultrasound contrast agents /
- Cancer /
- Molecular imaging /
- Therapy
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