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HER2阳性乳腺癌脑转移3例并文献复习

郑红梅, 吴新红, 原俊, 金立亭

郑红梅, 吴新红, 原俊, 金立亭. HER2阳性乳腺癌脑转移3例并文献复习[J]. 肿瘤防治研究, 2015, 42(06): 637-640. DOI: 10.3971/j.issn.1000-8578.2015.06.023
引用本文: 郑红梅, 吴新红, 原俊, 金立亭. HER2阳性乳腺癌脑转移3例并文献复习[J]. 肿瘤防治研究, 2015, 42(06): 637-640. DOI: 10.3971/j.issn.1000-8578.2015.06.023
ZHENG Hongmei, WU Xinhong, YUAN Jun, JIN Liting. Brain Metastases in Patients with HER2 Positive Breast Cancer: Three Cases Report and Literature Review[J]. Cancer Research on Prevention and Treatment, 2015, 42(06): 637-640. DOI: 10.3971/j.issn.1000-8578.2015.06.023
Citation: ZHENG Hongmei, WU Xinhong, YUAN Jun, JIN Liting. Brain Metastases in Patients with HER2 Positive Breast Cancer: Three Cases Report and Literature Review[J]. Cancer Research on Prevention and Treatment, 2015, 42(06): 637-640. DOI: 10.3971/j.issn.1000-8578.2015.06.023

HER2阳性乳腺癌脑转移3例并文献复习

基金项目: 湖北省卫生计生委重点项目(WJ2015MA016)
详细信息
    作者简介:

    郑红梅(1981-),女,博士在读,主治医师,主要从事乳腺肿瘤的基础和临床研究

    通信作者:

    吴新红,E-mail:wuxinhong_9@163.com

  • 中图分类号: R737.9

Brain Metastases in Patients with HER2 Positive Breast Cancer: Three Cases Report and Literature Review

  • [1] Aragon-Ching JB, Zujewski JA. CNS metastasis: an old problem in a new guise[J]. Clin Cancer Res, 2007, 13(6): 1644-7.
    [2] Hohensee I, Lamszus K, Riethdorf S, et al. Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases[J]. Am J Pathol, 2013, 183(1): 83-95.
    [3] Arslan C, Dizdar O, Altundag K. Systemic treatment in breast-cancer patients with brain metastasis[J]. Expert Opin Pharmacother, 2010, 11(7): 1089-100.
    [4] Steeg PS, Camphausen KA, Smith QR. Brain metastases as preventive and therapeutic targets[J]. Nat Rev Cancer, 2011, 11 (5): 352-63.
    [5] Zhang L, Sullivan PS, Goodman JC, et al. MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase[J]. Cancer Res, 2011, 71(3): 645-54.
    [6] Rama k r i s h n a N, Temi n S, Ch a n d a r l a p a t y S, e t a l . Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2-positive breast cancer and brain metastases: American Society of Clinical Oncology Clinical Practice Guideline[J]. J Clin Oncol, 2014, 32 (19): 2100-8.
    [7] Bartsch R, Berghoff A, Pluschnig U, et al. Impact of anti-HER2 therapy on overall survival in HER2-overexpressing breast cancer patients with brain metastases[J]. Br J Cancer, 2012, 106(1): 25 -31.
    [8] Brufsky AM, Mayer M, Rugo HS, et al. Central nervous system metastases in patients with HER2-positive metastatic breast cancer: incidence, treatment, and survival in patients from registHER[J]. Clin Cancer Res, 2011, 17(14): 4834-43.
    [9] Witzel I, Kantelhardt EJ, Milde-Langosch K, et al. Management of patients with brain metastases receiving trastuzumab treatment for metastatic breast cancer[J]. Onkologie, 2011, 34(6): 304-8.
    [10] Pestalozzi BC, Holmes E, de Azambuja E, et al. CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial(BIG 1-01)[J]. Lancet Oncol, 2013, 14(3): 24 4-8.
    [11] Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease[J]. Pharmacol Rev, 2005, 57(2): 173-85.
    [12] Pestalozzi BC, Brignoli S. Trastuzumab in CSF[J]. J Clin Oncol, 20 00, 18(11): 2349-51.
    [13] Zagouri F, Sergentanis TN, Bartsch R, et al. Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer: a systematic review and pooled analysis[J]. Breast Cancer Res Treat, 2013, 139(1): 13-22.
    [14] Metro G, Foglietta J, Russillo M, et al. Clinical outcome of patients with brain metastases from HER2-positive breast cancer treated with lapatinib and capecitabine[J]. Ann Oncol, 2011, 22 (3): 625-30.
    [15] Bachelot T, Romieu G, Campone M, et al. Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study[J]. Lancet Oncol, 2013, 14(1): 64-71.
    [16] Taskar KS, Rudraraju V, Mittapalli RK, et al. Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer[J]. Pharm Res, 2012, 29(3): 770-81.
    [17] Polli JW, Humphreys JE, Harmon KA, et al. The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}- 6- [5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4 -quinazolinamine (GW572016, lapatinib) disposition and drug interactions[J]. Drug Metab Dispos, 2008, 36(4): 695-701.
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  • 被引次数: 0
出版历程
  • 收稿日期:  2014-07-08
  • 修回日期:  2014-09-12
  • 刊出日期:  2015-06-24

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