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培美曲塞联合奈达铂一线方案治疗晚期肺腺癌的临床研究

段惠洁, 顾国民, 王秀丽, 刘春玲

段惠洁, 顾国民, 王秀丽, 刘春玲. 培美曲塞联合奈达铂一线方案治疗晚期肺腺癌的临床研究[J]. 肿瘤防治研究, 2014, 41(01): 61-64. DOI: 10.3971/j.issn.1000-8578.2014.01.014
引用本文: 段惠洁, 顾国民, 王秀丽, 刘春玲. 培美曲塞联合奈达铂一线方案治疗晚期肺腺癌的临床研究[J]. 肿瘤防治研究, 2014, 41(01): 61-64. DOI: 10.3971/j.issn.1000-8578.2014.01.014
DUAN Huijie, GU Guomin, WANG Xiuli, LIU Chunling. Clinical Curative Effects of Pemetrexed Plus Nedaplatin as First-line Treatment in Patients with Advanced Lung Adenocarcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(01): 61-64. DOI: 10.3971/j.issn.1000-8578.2014.01.014
Citation: DUAN Huijie, GU Guomin, WANG Xiuli, LIU Chunling. Clinical Curative Effects of Pemetrexed Plus Nedaplatin as First-line Treatment in Patients with Advanced Lung Adenocarcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(01): 61-64. DOI: 10.3971/j.issn.1000-8578.2014.01.014

培美曲塞联合奈达铂一线方案治疗晚期肺腺癌的临床研究

详细信息
    作者简介:

    段惠洁(1980-),女,硕士,主治医师,主要从事肺部肿瘤的临床诊断与治疗

    通信作者:

    刘春玲,E-mail:liudeyouxiang66@sina.com

  • 中图分类号: R730.53;R734.2

Clinical Curative Effects of Pemetrexed Plus Nedaplatin as First-line Treatment in Patients with Advanced Lung Adenocarcinoma

  • 摘要: 目的 观察和评价培美曲塞联合奈达铂与多西他赛联合奈达铂作为一线化疗方案治疗晚期肺腺癌的临床疗效和不良反应。方法 68例初治的晚期肺腺癌患者,体力状况(PS)评分0~2分,34 例培美曲塞 500 mg/m2联合奈达铂80 mg /m2;34例多西他赛75 mg/m2联合奈达铂80 mg /m2治疗。结果 入组的68例患者中有67例可评价疗效。培美曲塞组与多西他赛组比较疾病控制率分别为 45.45%和44.12%,中位生存时间分别为8.5月和8.2月,1年生存率为30.3%和26.5%。两组比较差异均无统计学意义(P >0.05)。在中性粒细胞减少和脱发的发生率上培美曲塞观察组均明显低于多西他赛对照组,差异有统计学意义(P<0.05)。其余恶心、呕吐、乏力等不良反应,两组比较差异无统计学意义。结论 培美曲塞与多西他赛分别联合奈达铂治疗晚期肺腺癌的疗效相当,但在不良反应的发生率上,培美曲塞组则显示出更好的优势。

     

    Abstract: Objective To observe and appraise the effi cacy and safety of pemetrexed and docetaxel combined with Nedaplatin respectively as the first-line therapy for patients with advanced lung adenocarcinoma . Methods Sixty-eight newly diagnosed patients with advanced lung adenocarcinoma, with physical status (PS) 0-2 were involved. Thirty four patients received nedaplatin 80 mg/m2 combined with pemetrexed 500 mg/m2. The rest of 34 patients received nedaplatin 80 mg/m2 combined with docetaxel 75 mg/m2. Results Sixty-seven patients were evaluable for effi cacy from the 68 cases. Disease control rate were 44.12 % vs. 44.12%, median survival time were 8.5 months vs. 8.2 months, and the 1-year survival rate were 30.3% vs. 26.5%, in the pemetrexed group vs. the Docetaxel group respectively. No statistically signifi cant differences were found between the two groups(P >0.05). The incidence of treatment emergent neutropenia and alopecia occurred in the observation group were signifi cantly lower than that in the control group(P<0.05). No signifi cant differences were found in adverse reactions, such as nausea, vomit and fatigue, of both groups (P >0.05). Conclusion The similar efficacy were observed in Pemetrexed plus Nedaplatin group and Docetaxel plus Nedaplatin group for advanced lung adenocarcinoma. However, Pemetrexed group showed more advantages on the incidence of adverse reactions.

     

  • [1] Socinski MA, Morris DE, Masters GA, et al. Chemotherapeutic managenment of stage Ⅳ non-small cell lung cancer [J]. Chest,2003,123(1 Suppl):226S-243S.
    [2] Scagliotti GV, Parikh P, von Pawel J, et al. Phase Ⅲ study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer[J].J Clin Oncol,2008,26(21):3543-51.
    [3] Scagliotti G, Hanna N, Fossella F, et al. The differential effi cacy of pemetrexed according to NSCLC histology: a review of two Phase Ⅲ studies[J].Oncologist,2009,14(3): 253-63.
    [4] Ciuleanu T, Brodowicz T, Zielinski C, et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study[J].Lancet,2009,374(9699):1432-40.
    [5] Fossella F, Pereira JR, von Pawel J, et al. Randomized, multinational, phase Ⅲ study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced nonsmall- cell lung cancer: the TAX 326 study group[J].J Clin Oncol, 20 03,21(16):3016-24.
    [6] Jiang L, Wang DY, Zhu ZH, et al. Phase Ⅱ study of carboplatin combined with weekly docetaxel in patients with advanced non-small cell lung cancer[J]. Cancer Chemother Pharmacol, 20 10,66(3):449-53.
    [7] Kataoka K, Suzuki R, Taniguchi H, et al. Phase Ⅰ/Ⅱ trial of docetaxel and carboplatin as a fi rst-line therapy in patients with stage Ⅳ non-small-cell lung cancer[J]. Lung,2006,184(3):133-9.
    [8] Zhang P,Feng FY,Wu LY, et al. Phase Ⅱ multicenter clinical trial of nedaplatin in the treatment of malignant tumors[J]. Zhongguo Zhong Liu Za Zhi, 2006, 28(3):230-4.[张频,冯奉仪, 吴令英,等.奈达铂治疗恶性肿瘤的临床研究[J].中华肿瘤杂 志,2006,3(28):230-4.]
    [9] Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small- cell lung cancer [ J] . N Engl J Med,2002,346(2):92-8.
    [10] Wang Q,Shan L. Clinical observation of the regimen for docetaxel combined with cisplatin and dedaplain chemotherapy in the treatment of advanced non-small cell lung cancer[J].Xin Jiang Yi Ke Da Xue Xue Bao,2009,32(7):901-3,905.[王强,单利.多西紫杉 醇联合顺铂与联合奈达铂化疗方案治疗晚期非小细胞肺癌的 临床观察[J].新疆医科大学学报,2009,32(7):901-3,905.]
    [11] Hanna N,Shepherd FA,Fossella FV, et al. Randomized phase Ⅲ trial of pemetrexed versus docetaxel in patients with nonsmall- cell lung cancer previously treated with chemotherapy[J]. J Clin Oncol,2004,22(9):1589-97.
    [12] Rodrigues-Pereira J, Kim JH, Magallanes M, et al. A randomized phase 3 trial comparing pemetrexed/carboplatin and docetaxel/ carboplatin as fi rst-line treatment for advanced, nonsquamous nonsmall cell lung cancer[J]. J Thorac Oncol,2011,6(11):1907-14.
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出版历程
  • 收稿日期:  2012-11-25
  • 修回日期:  2013-06-12
  • 刊出日期:  2014-01-24

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