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HU Yuqian, ZHENG Yi, NING Yong, XI Juan, XIE Shenggao. Epigenetic Mechanism of DNA Virus-mediated Carcinogenesis[J]. Cancer Research on Prevention and Treatment, 2016, 43(3): 230-233. DOI: 10.3971/j.issn.1000-8578.2016.03.013
Citation: HU Yuqian, ZHENG Yi, NING Yong, XI Juan, XIE Shenggao. Epigenetic Mechanism of DNA Virus-mediated Carcinogenesis[J]. Cancer Research on Prevention and Treatment, 2016, 43(3): 230-233. DOI: 10.3971/j.issn.1000-8578.2016.03.013

Epigenetic Mechanism of DNA Virus-mediated Carcinogenesis

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  • Received Date: June 17, 2015
  • Revised Date: August 24, 2015
  • Various kinds of virus could lead to carcinogenesis. Although those viruses belong to different viraceae, the molecular mechanisms they have evolved to cause tumor initiation show many similarities, which are targeting the key cellular proteins that regulate cell growth and proliferation. The interactions between virus and hosts occur at epigenetic level. This review summarizes the epigenetic mechanism of DNA virus proteins contributing to carcinogenesis.
  • [1]
    D'Costa ZJ, Jolly C, Androphy EJ, et al. Transcriptional repression of E-cadherin by human papillomavirus type 16 E6[J]. PLoS One, 20 12, 7(11): e48954.
    [2]
    Gorres KL, Daigle D, Mohanram S, et al. Activation and repression of Epstein-Barr Virus and Kaposi’s sarcoma-associated herpesvirus lytic cycles by short- and medium-chain fatty acids[J]. J Virol, 2014, 88(14): 8028-44.
    [3]
    McLaughlin-Drubin ME, Crum CP, Münger K. Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming[J]. Proc Natl Acad Sci U S A, 2011, 108(5): 21 30-5.
    [4]
    Zhang X, Hou J, Lu M. Regulation of hepatitis B virus replication by epigenetic mechanisms and microRNAs[J]. Front Genet, 2013, 4: 202.
    [5]
    Boosani CS, Agrawal DK. Methylation and microRNA-mediated epigenetic regulation of SOCS3[J]. Mol Biol Rep, 2015, 42(4): 85 3-72.
    [6]
    Tarocchi M, Polvani S, Marroncini G, et al. Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis[J]. World J Gastroenterol, 2014, 20(33): 11630-40.
    [7]
    Fernandez AF, Esteller M. Viral epigenomes in human tumorigenesis[J]. Oncogene, 2010, 29(10): 1405-20.
    [8]
    Clarke MA, Wentzensen N, Mirabello L, et al. Human papillomavirus DNA methylation as a potential biomarker for cervical cancer[J]. Cancer Epidemiol Biomarkers Prev, 2012, 21 (12): 2125-37.
    [9]
    Fang J, Zhang H, Jin S. Epigenetics and cervical cancer: from pathogenesis to therapy[J]. Tumour Biol, 2014, 35(6): 5083-93.
    [10]
    Trietsch MD, Nooij LS, Gaarenstroom KN, et al. Genetic and epigenetic changes in vulvar squamous cell carcinoma and its precursor lesions: a review of the current literature[J]. Gynecol Oncol, 2015, 136(1): 143-57.
    [11]
    Yang HJ. Aberrant DNA methylation in cervical carcinogenesis[J]. Chin J Cancer, 2013, 32(1): 42-8.
    [12]
    McLaughlin-Drubin ME, Crum CP, Münger K. Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming[J]. Proc Natl Acad Sci U S A, 2011, 108(5): 21 30-5.
    [13]
    Pannone G, Zamparese R, Pace M, et al. The role of EBV in the pathogenesis of Burkitt's Lymphoma: an Italian hospital based survey[J]. Infect Agent Cancer, 2014, 9(1): 34.
    [14]
    Yip TT, Ngan RK, Fong AH, et al. Application of circulating plasma/serum EBV DNA in the clinical management of nasopharyngeal carcinoma[J]. Oral Oncol, 2014, 50(6): 527-38.
    [15]
    Niller HH, Tarnai Z, Decsi G, et al. Role of epigenetics in EBV regulation and pathogenesis[J]. Future Microbiol, 2014, 9(6): 74 7-56.
    [16]
    Kim do N, Song YJ, Lee SK. The role of promoter methylation in Epstein-Barr virus (EBV) microRNA expression in EBV-infected B cell lines[J]. Exp Mol Med, 2011, 43(7): 401-10.
    [17]
    Lee H, Seo SY, Tiwari I, et al. Epstein-Barr Virus latent membrane protein 1 overcomes all-trans retinoic acid-induced apoptosis by inhibiting retinoic acid receptor-β60 expression[J]. Biochem Biophys Res Commun, 2012, 423(2): 313-8.
    [18]
    Tempera I, Lieberman PM. Epigenetic regulation of EBV persistence and oncogenesis[J]. Semin Cancer Biol, 2014, 26: 22-9.
    [19]
    Zhao C, Bu X. Promoter methylation of tumor-related genes in gastric carcinogenesis[J]. Histol Histopathol, 2012, 27(10): 12 71-82.
    [20]
    Anderton JA, Bose S, Vockerodt M, et al. The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and overexpressed in Hodgkin’s Lymphoma[J]. Oncogene, 2011, 30(17): 20 37-43.
    [21]
    Chen HS, Lu F, Lieberman PM. Epigenetic regulation of EBV and KSHV latency[J]. Curr Opin Virol, 2013, 3(3): 251-9.
    [22]
    Campbell M, Kung HJ, Izumiya Y. Long non-coding RNA and epigenetic gene regulation of KSHV[J]. Viruses, 2014, 6(11): 41 65-77.
    [23]
    Zhang YQ, Guo JS. Antiviral therapies for hepatitis B virus-related hepatocellular carcinoma[J]. World J Gastroenterol, 2015, 21(13): 38 60-6.
    [24]
    Zhu R, Zhang JS, Zhu YZ, et al. HBx-induced androgen receptor expression in HBV-associated hepatocarcinoma is independent of the methylation status of its promoter[J]. Histol Histopathol, 2011, 26 (1): 23-35.
    [25]
    Xirong L, Rui L, Xiaoli Y, et al. Hepatitis B virus can be inhibited by DNA methyltransferase 3a via specific zinc-finger-induced methylation of the X promoter[J]. Biochemistry(Mosc), 2014, 79 (2): 111-23.
    [26]
    Rongrui L, Na H, Zongfang L, et al. Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis[J]. Curr Pharm Des, 2014, 20(11): 1715-25.

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