Advanced Search
Ji Chunyan, . The Clinical Study of Leukemia Cell DNA And CD44[J]. Cancer Research on Prevention and Treatment, 1998, 25(6): 463-465.
Citation: Ji Chunyan, . The Clinical Study of Leukemia Cell DNA And CD44[J]. Cancer Research on Prevention and Treatment, 1998, 25(6): 463-465.
shu

The Clinical Study of Leukemia Cell DNA And CD44

  • Department of oncology, shandong madial university, Jinan 250012

More Information
    Graphical Abstract
    • Abstract
  • Objective:We studied the peripheral blood leukemic cell DNA, cell cycle and CD44changes of acute leukemia. blast crisis of CML and MDS--RAEB Patients to find their relationship with clinical feature in order to guide the clinical diagnosis and treatment. Methods :By using FCM, the DNA index. DNA ploidy and SPof 46 acute leukemia.10blast crisis of CML.5 MDS--RAEB patients and also blood CD44 expressions were studied in the above patients. Results: There was difference of DNA aneuploidy in acute leukemia.blast crisis of CML and MDS--RAEB Patients i DNA aneuploidy was higher in radical/relapsed acute leukemia patients than that of CR acute leukemia patients. The treatment of acute leukmia patients with diploids and lower DNA index was more effective. There was no difference of blood CD44 expression between patients and urinal controls. Conclusion =DNA index and aneuploidy may be regarded as an important reference in giving chemotherapy regimens of acate leukemia.
    • FullText(HTML)
    • References (7)
  • 1 Mc Culloch EA. Stem cell in normal and leukemic hemopoiesis. Blood, 1983, 62:1
    2 Barlogie B, Raber MN, Schumann J et al. Flow cytometry in clinical cancer research. Cancer Res,1983.43:3982
    3 张瑞欣.流式细胞术在急性白血病临床的应用.国外医学输血及血液学分册，1988,11(3):132
    4 宋华，郭淑芳，徐淑芝，等.用流式细胞仪测定小儿急性白血病细胞DNA及其临床意义研究.中华血液学杂志，1994,15(3):137
    5 左连富，郭建文，王敏彦.流式细胞仪在白血病化疗中的应用.中华血液学杂志1991,12(3):131
    6 Andreef M. Darzynkiewicz z. Sharpless TK, et aL. Discrimination of Human Leukemia Subtypes by Flow Cytometric Analysis of Cellular DNA and RNA. Blood. 1980.55:282
    7 王江方，张学先，张毅，等.急性淋巴细胞性白血病细胞及其骨髓基质细胞粘附分子表达和粘附行为的探讨.中国免疫学杂志，1996,12:290
    • Related Articles

  • Related Articles

    [1]LIU Hong, BIAN Lei, FANG Zhaohui, ZHANG Qianying, ZHU Hongwei, CHENG Jianxin. Characteristics of CD44 and CD24-marked Cervical Cancer Cells Subgroups[J]. Cancer Research on Prevention and Treatment, 2016, 43(5): 345-349. DOI: 10.3971/j.issn.1000-8578.2016.05.006
    [2]He Aina, Qi Weixiang, Tang Li′na, Shen Zan, Sun Yuanjue, Chen Jie, Yao Yang. Expression and Clinical Significance of CD133 and CD44 in Osteosarcoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(11): 1328-1332. DOI: 10.3971/j.issn.1000-8578.2012.11.012
    [3]WU Ming, LI Xue-jun, LI Zhen-yan, CHENG Lei, TANG Zhi, YUAN Xian-rui. Downregulation of Expression of Moesin in U251 Cells after Transfection with siRNA Leads PDGF and CD44 to Decrease[J]. Cancer Research on Prevention and Treatment, 2011, 38(02): 121-125. DOI: 10.3971/j.issn.1000-8578.2011.02.001
    [4]WANG Jing, LV Ke-jie, ZHU Guang-chang. Application of Serum DNA and hTERT in Diagnose of Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2008, 35(09): 656-658. DOI: 10.3971/j.issn.1000-8578.2624
    [5]LI Ying-jie, TAO Xiao-feng, HE Yan, FU Hong. Expression and Correlation of Ezrin and CD44 in Gastric Carcinoma[J]. Cancer Research on Prevention and Treatment, 2008, 35(03): 188-190. DOI: 10.3971/j.issn.1000-8578.1834
    [6]TONG Shu-lan, YIN Mei-ying, FEI Shao-hua, YI Long-zheng, YANG Ling-fang, SUN Hong-fu. Expression of ER、PR、p53 and DNA Content in Gallbladder Carcinoma[J]. Cancer Research on Prevention and Treatment, 2005, 32(03): 158-160. DOI: 10.3971/j.issn.1000-8578.143
    [7]FAN Zai-wen, WAN Yi-xin, AN ZHen-guang, et al. Study on expression of Bcl-2 and CD44 in human lung cancer[J]. Cancer Research on Prevention and Treatment, 2002, 29(05): 373-375. DOI: 10.3971/j.issn.1000-8578.820
    [8]ZHENG Wei, HUANG Jian-wen. Study on the Nuclear DNA Content in the Giant Cell Tumor of Bone by Image Cytometer[J]. Cancer Research on Prevention and Treatment, 2000, 27(02): 101-102. DOI: 10.3971/j.issn.1000-8578.2188
    [9]Wang Zhanxiang, . Study on the correlations of cellular DNA content with benign and malignant tumors of central nervous system[J]. Cancer Research on Prevention and Treatment, 1998, 25(6): 455-456.
    [10]Yang Ying, . The investigate of DNA contents in colorectal cancer[J]. Cancer Research on Prevention and Treatment, 1998, 25(1): 29-30.

Catalog

    Get Citation
    PDF
    XML
    Article views (1409) PDF downloads (306) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Download Center

    Links

    Contact Us

    Address：116 Zhuodaoquan South Road,
    Hongshan District, Wuhan（430079）

    Tel：027－87670126

    Email：zlfzyjzz@vip.163.com

    This work is licensed under a Creative Commons Attribution 3.0 License.

    Email Alert RSS
    Total visits： Visits today：

    Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return