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CHEN Yu, ZHAO Tong, CAI Qing-fa, WU Bing-xu, CHEN Mei-yan. Expression of bcl-2,bcl-6,CD10 Protein and Their Significance in Subgroups of Diffuse Large B-cell Lymphoma[J]. Cancer Research on Prevention and Treatment, 2008, 35(08): 563-565. DOI: 10.3971/j.issn.1000-8578.829
Citation: CHEN Yu, ZHAO Tong, CAI Qing-fa, WU Bing-xu, CHEN Mei-yan. Expression of bcl-2,bcl-6,CD10 Protein and Their Significance in Subgroups of Diffuse Large B-cell Lymphoma[J]. Cancer Research on Prevention and Treatment, 2008, 35(08): 563-565. DOI: 10.3971/j.issn.1000-8578.829
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Expression of bcl-2,bcl-6,CD10 Protein and Their Significance in Subgroups of Diffuse Large B-cell Lymphoma

  • 1.Department of Pathology; The 95th Military Hospital; Putian 351100; China; 2.Department of Pathology; Nanfang Medical University; 3.Department of Pathology; Affiliated Hospital of Putian University

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  • Received Date: August 28, 2007
  • Revised Date: November 11, 2007
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  • Objective To investigate the expression of bcl-2,bcl-6,CD10 protein and their significance in subgroups of diffuse large B-cell lymphoma. Methods Immunohistochemistry technique(SP method) was used to assess the expression levels of bcl-2,bcl-6,CD10 protein in 60 cases of diffuse large B-cell lymphoma. Results Expression of bcl-2,bcl-6 and CD10 protein was found in 33/60(55.0%),29/60(48.3%),28/60(46.7%) cases,respectively.The CD10/bcl-6 patterns were as follows: CD10(+)/bcl-6(+) 15 cases,25%;CD10(+)/bcl-6(-)13 cases, 21. 7 %; CD10 ( - ) / bcl-6 ( + ) 14 cases, 23. 3 %;CD10( - ) / bcl-6 ( - ) 18 cases, 30 %。Expression levels of the bcl-2 protein in CD10 ( + ) / bcl-6 ( + ) pattern was higher than that in CD10 ( - ) / bcl-6 ( - ) pattern ( P = 0. 037) . Conclusion 　The bcl-2 protein may be of value to distinct subgroup s of diffuse large B-cell lymphoma.
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