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Yuan ZhiQing, . Prognostic Significance And Heterogeneity In DNA PloidyOf Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 1996, 23(2): 72-75.
Citation: Yuan ZhiQing, . Prognostic Significance And Heterogeneity In DNA PloidyOf Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 1996, 23(2): 72-75.
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Prognostic Significance And Heterogeneity In DNA PloidyOf Esophageal Squamous Cell Carcinoma

  • Department of Pathology, Xinxiang Medical College, Henan

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  • Intratumoral heterogeneity in DNA ploidy was investigated in 80 cases of squamous cell carcinoma of the esophagus.Nuclear DNA content was determined formultiple samples obtained from the same tumor,using a flow cytometric(FCM)technique. The incidence of DNA aneuploidy was 88. 8% in this series, and DNA indicesranged from 0. 77-1. 74 of 80 cases,38 (47. 5 %)showed intratumoral heterogeneityin DNA ploidy. The 5-year-survival rate was significantly lower in the patients withtumors of heterogeneity in DNA ploidy(THDP)than those with non-THDP(P0. 025).Significance and mechanisms responsible for intratumoral heterogeneity inDNA ploidy are discussed from the aspect of tumor progression.
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