The Effect of Female hormones in stopping growth of MNU-induced Urinary bladder tumors in Rats and reducing the size of tumors in Mice

Spayed Wistar rats were given 0. 5mg MNU per week for 4 weeks, administered intravesicular. Estradol Valerate or restosterone Proprionate were then injected intramuscularly into the gonadectomied animals weekly for a period of 20 weeks,Estradiol Valerate was seen to have the effect of controlling tumor growth whileTestosterone Proprionate accelerated tumor growth. Further experimentsdemonstrated that Estradiol Benzoate, Estradiol Valerat, Diethystilbestrol, Megestrol and Progesterone are effective in treating tumor types BST 739 and BTT739 inmice.