The Relationship between EB Virus ZEBRA/igG Change Regulation and Nasopharyngeal Carcinoma

CAO Su-mei; HUANG Teng-bo; JIAN Shao-wen

Cancer Research on Prevention and Treatment > 1999 > 26(5): 382-384.

CAO Su-mei, HUANG Teng-bo, JIAN Shao-wen, . The Relationship between EB Virus ZEBRA/igG Change Regulation and Nasopharyngeal Carcinoma[J]. Cancer Research on Prevention and Treatment, 1999, 26(5): 382-384.

Citation:

PDF (190 KB)

The Relationship between EB Virus ZEBRA/igG Change Regulation and Nasopharyngeal Carcinoma

Cancer Institute, Sun yat Sun University, Guangzhou 510060

More Information

Graphical Abstract

Abstract

Abstract

Objective to explain the change regulation of ZEBRA/IgG in the different state of nasopharyngeal canceration. Methods ZEBRA/IgG were detected in ELISA method to the different state screening samples in suihui area.including:nasopharyngeal carcinoma 27,high risk people 50,VCA/IgA positive person 50,all negative person 30. Results The positive rate of ZEBRA/IgG in the group of NPCwre 90 9%,which is higher than the contrast groups.There is significance between them(P0 01).The average time from ZEBRA/IgG first positive to be pathonalagly diagnosised is 3 5(2 62 4 38)years and the titer of the antibody gradually rise to the highest level. Conclusion The study suggested that ZEBRA/IgG might be as a diagnosis marker to NPC.The patients whose ZEBRA/IgG consistly keep high or rise should be highly suspected of NPC.
- Nasopbaryngeal canceration,
- ZEBRA/I_gG,
- EB virus

FullText(HTML)

References (10)

References

[1]	Countryman J,et al.Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterge-neous viral DNA.Proc Natl Acad Sci U S A,1985,82(12):4085～4089
[2]	Chevallier GA,et al.Both Epstein-Barr virus(EBV)-encoded trans-acting factors,EB1 and EB2,are required to activate transcription from an EBV early promoter.EMBO J,1986,5(12):3243～3249
[3]	Taylor N,et al.Expression of the BZLF1 latency-disrupting gene differs in standard and defective Epstein-Barr viruses.J Virol,1989,63(4):1721～1728
[4]	Rooney CM,et al.The spliced BZLF1 gene of Epstein-Barr virus(EBV)transactivates an early EBV promoter and induces the virus productive cycle.J Virol,1989,63(7):3109～3116
[5]	Irene joab,et al.Detection of anti-Epstein-Barr-virus transactivator (ZEBRA)antibodies in sera from patients with nasopharyngeal carcinoma.Int J Cancer,1991,48:647～649
[6]	Yip TT,et al.A possible prognostic role of immunoglobulin-G antibody against recombinant Epstein-Barr virus BZLF-1 transactivator protein ZEBRA in patients with nasopharyngeal carcinoma.Cancer,1994,74(9):2414～2424
[7]	Brooks L,et al.Epstein-Barr virus latent gene transcription in nasopharyn-geal carcinoma cell:coexpression of EBNA1、LMP1 and LMP2 transcripts J Virol,1992,66(5):2689～2697
[8]	Dominique MR,et al.Qualitative analysis of the Epstein-Barr virus lytic gene in nasopharyneal carcinoma biopsies.Journal of General Virology,1995,76：1401～1408
[9]	黄腾波，等.鼻咽癌优化筛查方案-鼻咽癌的早期检出.癌症，1997，16(4)：245～247
[10]	闵华庆，等.EB病毒与鼻咽癌相关的前瞻性研究.癌症，1991，10(5)：367～369

[1]	XU Tian, YANG Lu, YUAN Fangqin, HE Xia, YIN Li. Relation Between EB Virus Infection and Curative Effect, Prognosis of Patients with Early-stage Extranodal Nasal-type NK/T-cell Lymphoma[J]. Cancer Research on Prevention and Treatment, 2021, 48(11): 999-1005. DOI: 10.3971/j.issn.1000-8578.2021.21.0216
[2]	JIN Zaishun, YU Jianbo, GUO Sufen, LI Zhiqiang, AN Jindan, WANG Ying, SONG Hualin. Establishment of Resting B Cell Model Infected with Latent EB Virus in Peripheral Blood[J]. Cancer Research on Prevention and Treatment, 2014, 41(06): 523-526. DOI: 10.3971/j.issn.1000-8578.2014.06.003
[4]	CAI Yong-lin, ZHENG Yu-ming, CHENG Ji-ru, ZHONG Wei-ming, LI Jun, MO Yong-kun, ZHONG Qing-yan. Distribution Analysis for Antibody Levels of Epstein-Barr Virus VCA/IgA, Rta/IgG and EBNA1/IgA in Different Classified Populations from High Risk Area of Nasopharyngeal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2010, 37(09): 1073-1076. DOI: 10.3971/j.issn.1000-8578.2010.09.027
[6]	ZHENG Yu-ming, TANG Min-zhong, CAI Yong-lin, LI Jun, CHENG Ji-yu, MO Yong-kun. Case-control Study on Non-viral Risk Factors of Nasopharyngeal Carcinoma with IgA Antibodies to Epstein-Barr Virus Capsid Antigens Positive[J]. Cancer Research on Prevention and Treatment, 2008, 35(10): 744-747. DOI: 10.3971/j.issn.1000-8578.2858
[7]	OU Xiao-bo, CHEN Xiao-yi. Relationship of EB Virus Latent Membrane Protein 1 and E-cadherin,ICAM-1 in Nasopharyngeal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2008, 35(07): 499-501. DOI: 10.3971/j.issn.1000-8578.1859
[8]	TANG Wen-tai, GUO Rui-zhen, HE Miao-xia, et al. A study of the bcl-2 expression in B-cell lymphomas of gastrointestinal tract and the association of the latter with Epstein-Barr Virus[J]. Cancer Research on Prevention and Treatment, 2002, 29(06): 439-441. DOI: 10.3971/j.issn.1000-8578.281
[9]	ZOU Xian-jing, LUO Kai, LIU Yin, et al, . Fluorescence quantitative PCR detected Infection of Epstein-Barr virus[J]. Cancer Research on Prevention and Treatment, 2002, 29(03): 173-174. DOI: 10.3971/j.issn.1000-8578.1713
[10]	Guo Feng, . Detection of Epstein—Barr Virus in Carcinoma of the Cervix[J]. Cancer Research on Prevention and Treatment, 1998, 25(2): 81-82.

Cited By

Get Citation

PDF

XML

Article views (1335) PDF downloads (562)

Turn off MathJax

Article Contents

Abstract

References

The Relationship between EB Virus ZEBRA/igG Change Regulation and Nasopharyngeal Carcinoma

Abstract

References

Related Articles

Catalog

Contact Us

The Relationship between EB Virus ZEBRA/igG Change Regulation and Nasopharyngeal Carcinoma

Abstract

References

Related Articles

Catalog

Contact Us

Export File

Citation

Format

Content