Deletions of MTS1/p 16 Gene in Lymphoma

Objective To investigate the alteration of MTS1/p 16 gene in lymphoma. Methods A total of 34 non-Hodgkin's lymphoma and 15 controls DNA specimens were examined for homozygous deletion of MTS1/p 16 gene Exon2 by Differential PCR. Results The results showed that 4 of 34 non-Hodgkin's lymphoma DNA specimens were found the deletion of MTS1/p 16 gene Exon2, with a 11 8%(4/34) MTS1/p 16 gene EXon2 deletion rate. Conclusion The results suggest that MTS1/p 16 gene alterations may play a role in the progression of non-Hodgkin's lymphoma.