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  • Received Date: March 06, 2012
  • Revised Date: May 31, 2012
  • [1]
    Bartek J,Lukas J.Chk1 and Chk2 kinases in checkpoint control and cancer[J].Cancer Cells,2003,3(5):421-9.
    [2]
    Huen MS,Sy SM,Chen J.BRCA1 and its toolbox for the maintenance of genome integrity[J].Nat Rev Mol Cell Biol,2010,11(2):138-48.
    [3]
    Kim H,Chen J.New players in the BRCA1-mediated DNA damage responsive pathway[J].Mol Cells,2008,25(4):457-61.
    [4]
    Ayoub N,JeyasekharanAD,Bermal JA,et al.Paving the way for H2AX phosphorylation:chromatin changes in the DNA damage response[J].Cell Cycle,2009,8(10):1494-500.
    [5]
    Fernandez-Capetillo O,Celeste A,Nussenzweig A.Focusing on foci:H2AX and the recruitment of DNA-damage response factors[J].Cell Cycle,2003,2(5):426-7.
    [6]
    Celeste A,Petersen S,Romanienko PJ,et al.Genomic instability in mice lacking histone H2AX[J].Science,2002,296(5569):922-7.
    [7]
    Rogakou EP,Pilch DR,Orr AH,et al.DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 [J].Biol Chem,1998,273(10):5858-68.
    [8]
    Celeste A,Difilippantonio S,Difilippantonio MJ,et al.H2AX haploinsufficiency modifies genomic stability and tumor susceptibility[J].Cell,2003,114(3):371-83.
    [9]
    Bassing CH,Chua KF,Sekiguchi J,et al.Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX [J].Proc Natl Acad Sci U S A,2002,99(12):8173-8.
    [10]
    van Gent DC,Hoeijmakers JH,Kanaar R.Chromosomal stability and the DNA double-stranded break connection [J].Nat Rev Genet,2001,2(3):196-206.
    [11]
    Petersen S,Casellas R,Reina-San-Martin B.AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching [J].Nature,2001,414(6864):660-5.
    [12]
    Xie A,Puget N,Shim I,et al.Control of sister chromatid recombination by histone H2AX [J].Mol Cell,2004,16(6):1017-25.
    [13]
    Rogakou EP,Boon C,Redon C,et al.Megabase chromatin domains involved in DNA double-strand breaks in vivo[J].J Cell Biol,1999,146(5):905-16.
    [14]
    Chowdhury D,Keogh MC,Ishii H,et al.gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair[J].Mol Cell,2005,20(5):801-9.
    [15]
    Keogh MC,Kim JA,Downey M,et al.A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery[J].Nature,2006,439(7075):497-501.
    [16]
    Downs JA,Lowndes NF,Jackson SP.A role for Saccharomyces cerevisiae histone H2A in DNA repair[J].Nature,2000,408(6815):1001-4.
    [17]
    Downs JA,Allard S,Jobin-Robitaille O,et al.Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites[J].Mol Cell,2004,16(6):979-90.
    [18]
    van Attikum H,Fritsch O,Hohn B,et al.Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair[J].Cell,2004,119(6):777-88.
    [19]
    Morrison AJ,Highland J,Krogan NJ,et al.INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair[J].Cell,2004,119(6):767-75.
    [20]
    Kobayashi J,Tauchi H,Sakamoto S,et al.NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain[J].Curr Biol,2002,12(21):1846-51.
    [21]
    Ward IM,Minn K,Jorda KG,et al.Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX[J].Biol Chem,2003,278(22):19579-82.
    [22]
    Stewart GS,Wang B,Bignell CR,et al.MDC1 is a mediator of the mammalian DNA damage checkpoint[J].Nature,2003,421(6926):961-6.
    [23]
    Foster ER,Downs JA.Histone H2A phosphorylation in DNA double-strand break repair[J].FEBS J,2005,272(13):3231-40.
    [24]
    Wood JL,Singh N,Mer G,et al.MCPH1 Functions in an H2AX-dependent but MDC1-independent Pathway in Response to DNA Damage[J].J Biol Chem,2007,282(48):35416-23.
    [25]
    Durocher D,Smerdon SJ,Yaffe MB,et al.The FHA domain in DNA repair and checkpoint signaling[J].Cold Spring Harb Symp Quant Biol,2000,65:423-31.
    [26]
    Manke IA,Lowery DM,Nguyen A,et al.BRCT repeats as phosphopeptide-binding modules involved in protein targeting[J].Science,2003,302(5645):636-9.
    [27]
    Yu X,Chini CC,He M,et al.The BRCT domain is a phospho-protein binding domain[J].Science,2003,302(5645):639-42.
    [28]
    Clapperton JA,Manke IA,Lowery DM,et al.Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer[J].Nat Struct Mol Biol,2004,11(6):512-8.
    [29]
    Williams RS,Lee MS,Hau DD,et al.Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1[J].Nat Struct Mol Biol,2004,11(6):519-25.
    [30]
    Scully R,Chen J,Ochs RL,et al.Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage [J].Cell,1997,90(3):425-35.
    [31]
    Schultz LB,Chehab NH,Malikzay A,et al.p53 binding protein 1(53BP1)is an early participant in the cellular response to DNA double-strand breaks[J].Cell Biol,2000,151(7):1381-90.
    [32]
    Goldberg M,Stucki M,Falck J,et al.MDC1 is required for the intra-S-phase DNA damage checkpoint[J].Nature,2003,421(6926):952-6.
    [33]
    Lou Z,Minter-Dykhouse K,Wu X,et al.MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways[J].Nature,2003,421(6926):957-61.
    [34]
    Carney JP,Maser RS,Olivares H,et al.The hMre11/hRad50 protein complex and Nijmegen breakage syndrome:linkage of double-strand break repair to the cellular DNA damage response [J].Cell,1998,93(3):477-86.
    [35]
    Xu X,Lee J,Stern DF.Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1[J].Biol Chem,2004,279(33):34091-4.
    [36]
    Jowsey PA,Doherty AJ,Rouse J.Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation [J].Biol Chem,2004,279(53):55562-9.
    [37]
    Yamane K,Wu X,Chen J.A DNA damage-regulated BRCT-containing protein,TopBP1,is required for cell survival [J].Mol Cell Biol,2002,22(2):555-66.
    [38]
    Rodriguez M,Yu X,Chen J,et al.Phosphopeptide binding specificities of BRCA1 COOH-terminal(BRCT)domains [J].J Biol Chem,2003,278(52):52914-8.
    [39]
    Lukas C,Melander F,Stucki M,et al.Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention [J].EMBO J,2004,23(13):2674-83.
    [40]
    Stucki M,Clapperton JA,Mohammad D,et al.MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks [J].Cell,2005,123(7):1213-26.
    [41]
    Glover JN,Williams RS,Lee MS.Interactions between BRCT repeats and phosphoproteins:tangled up in two [J].Trends Biochem Sci,2004,29(11):579-85.
    [42]
    Lee MS,Edwards RA,Thede GL,et al.Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail[J].J Biol Chem,2005,280(37):32053-6.
    [43]
    Botuyan MV,Nominé Y,Yu X,et al.Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains[J].Structure,2004,12(7):1137-46.
    [44]
    Shiozaki EN,Gu L,Yan N,et al.Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide:implications for signaling [J].Mol Cell,2004,14(3):405-12.
    [45]
    Lou Z,Minter-Dykhouse K,Franco S,et al.MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals [J].Mol Cell,2006,21(2):187-200.
    [46]
    Stucki M,Jackson SP.MDC1/NFBD1:a key regulator of the DNA damage response in higher eukaryotes[J].DNA Repair(Amst),2004,3(8-9):953-7.
    [47]
    Celeste A,Fernandez-Capetillo O,Kruhlak MJ,et al.Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks [J].Nat Cell Biol,2003,5(7):675-9.
    [48]
    Bekker-Jensen S,Lukas C,Melander F,et al.Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1 [J].Cell Biol,2005,170(2):201-11.
    [49]
    Iwabuchi K,Basu BP,Kysela B,et al.Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA [J].J Biol Chem,2003,278(38):36487-95.
    [50]
    Huyen Y,Zgheib O,Ditullio RA Jr,et al.Methylated lysine 79 of histoneH3 targets 53BP1 to DNA double-strand breaks[J].Nature,2004,432(7015):406-11.
    [51]
    Falck J,Coates J,Jackson SP.Conserved modes of recruitment of ATM,ATR and DNA-PKcs to sites of DNA damage[J].Nature,2005,434(7033):605-11.
    [52]
    You Z,Chahwan C,Bailis J,et al.ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1 [J].Mol Cell Biol,2005,25(13):5363-79.

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