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LIANG Rong, HUANG Gao-sheng, WANG Zhe, FENG Ji-liang, GUO Ying, YANG Guo-rong, WANG Juan-hong, ZHANG Wei-ping. Apoptosis of HL60/VCR Cells Induced by Topotecan[J]. Cancer Research on Prevention and Treatment, 2004, 31(12): 736-738. DOI: 10.3971/j.issn.1000-8578.2064
Citation: LIANG Rong, HUANG Gao-sheng, WANG Zhe, FENG Ji-liang, GUO Ying, YANG Guo-rong, WANG Juan-hong, ZHANG Wei-ping. Apoptosis of HL60/VCR Cells Induced by Topotecan[J]. Cancer Research on Prevention and Treatment, 2004, 31(12): 736-738. DOI: 10.3971/j.issn.1000-8578.2064
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Apoptosis of HL60/VCR Cells Induced by Topotecan

    Abstract
  • Objective To gain insight into the mechanisms of topotecan(TPT) inducing apoptosis of acute myelogenous leukemia multidrug-resistant HL60/VCR cells. Methods Exposed HL60/VCR cells to different concentrations of TPT, morphologic evidence for apoptosis was determined by Wright-Gimsa and Acridine Orange/ethidium bromide(AO/EB) staining. Cell cycle, Sub-G1 and Annexin V FITC staining were detected by flow cytometry. The expression of active caspase-3, bcl-2 and Pgp were detected by Western blot. Results HL...
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