Mendelian Randomization Analysis of Research on Risk Factors for Gastric Cancer

WANG Mengyuan; XU Hengmin; WANG Jingxuan; PAN Kaifeng; LI Wenqing

doi:10.3971/j.issn.1000-8578.2023.22.1411

Cancer Research on Prevention and Treatment > 2023 > 50(5): 470-476. > DOI: 10.3971/j.issn.1000-8578.2023.22.1411

WANG Mengyuan, XU Hengmin, WANG Jingxuan, PAN Kaifeng, LI Wenqing. Mendelian Randomization Analysis of Research on Risk Factors for Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2023, 50(5): 470-476. DOI: 10.3971/j.issn.1000-8578.2023.22.1411

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Mendelian Randomization Analysis of Research on Risk Factors for Gastric Cancer

1.
Department of Cancer Epidemiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China
2.
School of Basic Medical Science, Peking University, Beijing 100191, China

Funding:

National Natural Science Foundation of China 82273704

More Information

Corresponding author:
LI Wenqing, E-mail: wenqing_li@bjmu.edu.cn
Received Date: November 27, 2022
Revised Date: January 29, 2023
Available Online: January 12, 2024

Graphical Abstract

Abstract

Abstract

Objective
To understand the application and research progress of Mendelian randomization (MR) studies related to gastric cancer and provide a scientific basis for gastric cancer prevention.
Methods
Published studies on risk factors of gastric cancer based on MR methods were searched in PubMed, Web of Science, EMBASE, CNKI, and WANFANG DATA from the establishment of each database to November 1^9th, 2022. Two researchers examined the eligibility of studies, extracted key information, and assessed the research quality independently.
Results
A total of 30 publications published from 2016 to 2022 were included in the study, and 20 were judged to be of high quality. These studies examined the relationship between behaviors and lifestyle factors, anthropometric characteristics, indicators of biological exposure, and other pathological conditions and gastric cancer, and the results suggest potential causal associations between smoking and other factors and the risk of gastric cancer.
Conclusion
Previous MR studies extensively investigated the causal association between internal and external exposures or traits and gastric cancer and provided positive evidence of gastric cancer etiology. However, MR studies may be subject to methodological limitations. Interpretation of results needs to be approached with caution, which necessitates the integration with biological plausibility and evidence from observation studies.
- Gastric cancer,
- Mendelian randomization,
- Causality

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Competing interests: The authors declare that they have no competing interests.

References (43)

References

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Mendelian Randomization Analysis of Research on Risk Factors for Gastric Cancer