Eff iciency of Body2γ2Knife for Patients with Primary Hepatocellular Carcinoma

Objective 　To investigate the short and long2term therapeutic effectiveness and complication of body2γ2knife in patient s with small hepatocellular carcinoma ( SHCC) . Methods 　Thirty2seven patient s with SHCC were t reated by body2γ2knife therapy. The isodose curve (50 %～60 %) was covered about planning target volume ( PTV), The isodose curve (60 %～70 %) was covered about gross tumor volumes ( GTV) . The biological effective dose is 80 Gy at least to the GTV. Twenty2seven patient s was t reated in combination with TACE 1 or 2 times. Results 　Tumor disappeared in 9 patient s, tumor size decreased in 22 patient s, remained unchanged in 4 patient s, and enlarged in 2 patient s. The local cont rol rates were 83. 78 %(31/ 37) . The overall survival rate of 1 、2 、3 、4 、52year was 78. 38 %(29/ 37), 62. 16 %(23/ 37), 43. 24 %(16/ 37), 32. 43 %(11/ 37), 33. 3 %(5/ 15) 。The median follow2up duration was 27 months. The overall survival rate of 4 year with solitary lesion was 55. 56 % (11/ 20) . The therapeutic effectiveness is comparable to radical operation with acceptable complication. Conclusion 　Body2γ2knife radiotherapy is a feasible approach of radical cure for patient s refuse operation or are not suitable for operation. However, the suitable total dose and f ractional dose need further discussion.