Study on the relationship between the mutations of p16 gene and endometrial carcinoma

Objective To study the relationship between the alterations of p16 gene and the occurrence and development of the endometrial carcinoma. Methods The alterations of p16 gene were studied by ploymerase chain reaction single strand conformation polymorphism(PCR SSCP) and DNA sequencing in 40 endometrial carcinomas. Results The exon 2 of p16 gene occurred 522bp homozygous deletion in 12 cases. The point mutations at the same site were detected in 10 cases, and one of mutating sites was GTC→AAT(Val126Asn) on...