Relationship between expressions of P-glycoprotein and p53 protein in osteosarcoma

Objective To study the expression of P glycoprotein in osteosarcoma and the correlation with the expression of p53 gene. Methods The P glycoprotein and p53 expressions of 33 osteosarcomas were detected by immuno histochemistry (S P) method.There were 24 in males,9 in females and with the mean age of 20.6 years, 5 inⅡ A, 23 inⅡ B and 5 inⅢ B . Results 9 patients were followed up with the average time of 1 year and 7 months, 3 recurred and 11 metastated to the lungs and 6 died. the positiv...