Effects of telomerase inhibitor combined with radiotherapy on gastric cancer in mice

Objective To investigate the treatment effects of telomerase inhibitor for animal tumor in vivo and the radiosensitive value of telomerase inhibitor. Methods The telomerase inhibitor AZT and radiotherapy were used to treat gastric cancers(SGC 7901) xenograft in BALB/c mice .The tumor was weekly measured and telomerase activity was examined by Semi TRAP assy. Results The tumor size of mice increased 3.3 times in untreated group. AZT, radiotherapy and AZT combined with radiotherapy reduced tumor volume o...