Relationship between p53 (exon 7) mutation and HPV infection in human cervical cancers
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Abstract
Objective To investigate the relationship between p53 (exon 7) mutations and human papillomavirus (HPV) 16?18 infections in human cervical cancer. Methods p53 (exon 7) mutations and HPV16?18 infections were examined by polymerase chain reaction (PCR) and single strand conformation polymorphism (SSCP) and restriction fragment length polymorphism(RFLP) analysis in the 49 cervical cancers. Results Significant difference (χ 2 =55.901, P <0.001) between p53 (exon7) mutations 5/49 (10.20%) and HPV in...
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