Expressions of VEGF,p53 and MMP-2 in human non-small cell lung cancer and the relationship between them and tumor angiogenesis and lymph node metastasis

Objective To investigate the relationship between the expression of VEGF, p53 and MMP 2 in human non small cell lung cancer(NSCLC)and tumor angiogenesis and lymph node metastasis. Methods the expression of VEGF,p53, MMP 2 and IMVD in 95 patients with NSCLC were examined using immunohistochemical methods(SP). Results The positive expression of VEGF,p53 and MMP 2 was associated with IMVD and lymph node metastases of NSCLC( P <0.05). Conclusion The results suggested that VEGF,p53,MMP 2 may play an...