The Relationship between HPV16/18 Infection and COX-2 Protein Expression in Cervical Adenocarcinoma
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Abstract
Objective To study the role of 16,18 human papilloma virus (HPV16/18) infection in the carcinogenesis of cervical adenocarcinoma,and to analyze the relationship between HPV16/18 infection and cyclooxygenase-2(COX-2) protein expression. Methods The expressions of HPV16/18DNA and COX-2 protein were determined by tissue microarray combined with in situ hybridization and immunohistochemistry in 86 cases of cervical adenocarcinoma and 24 cases of cervical chronic inflammation. Results The positive rates of HPV16/1...
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