Detection and Evaluation of Serum Proteomic Patterns by SELDI-TOF-MS in Early Gastric Cancer

Objective To detect the serum proteomic patterns using SELDI-TOF-MS ProteinChip array technology in gastric cancer,screen biomarker candidates,build diagnostic models and evaluate its clinical significance in early gastric cancer. Methods SELDI-TOF-MS ProteinChip was used to detect the serum proteomic patterns of 34 patients with gastric cancer (12 cases of Ⅰ/Ⅱstage and 22 cases of Ⅲ/Ⅳ stage) and 30 healthy people.The diagnostic models were developed and validated by discriminant analysis. Results The model c...