Clinical Observation in Temozolomide Combined with Radiotherapy in Treatment of Postoperative Malignant Glioma

Objective To compare the efficiency and safety of temozolomide administered concomitantly and adjuvantly to radiotherapy versus radiotherapy alone in patients with postoperative malignant glioma. Methods 38 postoperative patients with pathologically confirmed malignant glioma were randomly assigned to receive temozolomide 75mg/m² /d orally,concomitantly with radiotherapy (experiment group; n=22),followed by six cycles of temozolomide (150mg/m² /d orally),or radiotherapy alone (control group; n=16).The pa...